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company name :
Tocris Bioscience
product type :
chemical
product name :
FAK Inhibitor 14
catalog :
3414/10
quantity :
10 mg (also 50 mg)
price :
165 USD
more info or order :
citations: 29
Reference
Steinestel K, Trautmann M, Jansen E, Dirksen U, Rehk xe4 mper J, Mikesch J, et al. Focal adhesion kinase confers pro-migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma. Mol Oncol. 2020;14:248-260 pubmed publisher
Jia C, Keasey M, Malone H, Lovins C, Sante R, Razskazovskiy V, et al. Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF. Exp Neurol. 2019;312:20-32 pubmed publisher
Ni Y, Wang X, Yin X, Li Y, Liu X, Wang H, et al. Plectin protects podocytes from adriamycin-induced apoptosis and F-actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway. J Cell Mol Med. 2018;22:5450-5467 pubmed publisher
Bastounis E, Yeh Y, Theriot J. Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin. Mol Biol Cell. 2018;29:1571-1589 pubmed publisher
Jia J, Martin T, Ye L, Meng L, Xia N, Jiang W, et al. Fibroblast activation protein-? promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways. Int J Mol Med. 2018;41:275-283 pubmed publisher
Xie Z, Enkhjargal B, Reis C, Huang L, Wan W, Tang J, et al. Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats. J Am Heart Assoc. 2017;6: pubmed publisher
Jantaree P, Lirdprapamongkol K, Kaewsri W, Thongsornkleeb C, Choowongkomon K, Atjanasuppat K, et al. Homodimers of Vanillin and Apocynin Decrease the Metastatic Potential of Human Cancer Cells by Inhibiting the FAK/PI3K/Akt Signaling Pathway. J Agric Food Chem. 2017;65:2299-2306 pubmed publisher
Visavadiya N, Keasey M, Razskazovskiy V, Banerjee K, Jia C, Lovins C, et al. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Commun Signal. 2016;14:32 pubmed
Rengarajan M, Hayer A, Theriot J. Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes. PLoS Pathog. 2016;12:e1005603 pubmed publisher
An X, Zhao Z, Luo Y, Zhang R, Tang X, Hao D, et al. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget. 2016;7:24719-33 pubmed publisher
Webber P, Park C, Qui M, Ramalingam S, Khuri F, Fu H, et al. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience. 2015;2:765-776 pubmed
Gutiérrez J, Droppelmann C, Contreras O, Takahashi C, Brandan E. RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice. PLoS ONE. 2015;10:e0135005 pubmed publisher
McLane J, Ligon L. Palladin mediates stiffness-induced fibroblast activation in the tumor microenvironment. Biophys J. 2015;109:249-64 pubmed publisher
Thakur R, Trivedi R, Rastogi N, Singh M, Mishra D. Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep. 2015;5:10194 pubmed publisher
Jouve N, Bachelier R, Despoix N, Blin M, Matinzadeh M, Poitevin S, et al. CD146 mediates VEGF-induced melanoma cell extravasation through FAK activation. Int J Cancer. 2015;137:50-60 pubmed publisher
Gustafsson K, Jamalpour M, Trinh C, Kharas M, Welsh M. The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease. J Hematol Oncol. 2014;7:45 pubmed publisher
Shih C, Lacagnina M, Leuer Bisciotti K, Proschel C. Astroglial-derived periostin promotes axonal regeneration after spinal cord injury. J Neurosci. 2014;34:2438-43 pubmed publisher
Löffek S, Hurskainen T, Jackow J, Sigloch F, Schilling O, Tasanen K, et al. Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling. PLoS ONE. 2014;9:e87263 pubmed publisher
Aoyama D, Hashimoto N, Sakamoto K, Kohnoh T, Kusunose M, Kimura M, et al. Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells. PLoS ONE. 2013;8:e81133 pubmed publisher
Vandenberghe M, Raphaël M, Lehen kyi V, Gordienko D, Hastie R, Oddos T, et al. ORAI1 calcium channel orchestrates skin homeostasis. Proc Natl Acad Sci U S A. 2013;110:E4839-48 pubmed publisher
Wiel C, Augert A, Vincent D, Gitenay D, Vindrieux D, Le Calve B, et al. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death Dis. 2013;4:e855 pubmed publisher
Maleńczyk K, Jazurek M, Keimpema E, Silvestri C, Janikiewicz J, Mackie K, et al. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. J Biol Chem. 2013;288:32685-99 pubmed publisher
Tsai C, Wu H, Lin C, Lin Y, Chao A, Wang T, et al. Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor ? (ER?). PLoS ONE. 2013;8:e72999 pubmed publisher
Keasey M, Kang S, Lovins C, Hagg T. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal. 2013;11:35 pubmed publisher
Mendoza Naranjo A, El Naggar A, Wai D, Mistry P, Lazic N, Ayala F, et al. ERBB4 confers metastatic capacity in Ewing sarcoma. EMBO Mol Med. 2013;5:1087-102 pubmed publisher
Barbelanne M, Song J, Ahmadzai M, Tsang W. Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis. Hum Mol Genet. 2013;22:2482-94 pubmed publisher
Crow A, Webster K, Hohlfeld E, Ng W, Geissler P, Fletcher D. Contractile equilibration of single cells to step changes in extracellular stiffness. Biophys J. 2012;102:443-51 pubmed publisher
Afrikanova I, Yebra M, Simpkinson M, Xu Y, Hayek A, Montgomery A. Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of ?-cells from human pluripotent stem cells. J Biol Chem. 2011;286:36042-52 pubmed publisher
Tu H, Xu C, Zhang W, Liu Q, Rondard P, Pin J, et al. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci. 2010;30:749-59 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3414
SKU :
3414/10
product name :
FAK Inhibitor 14
description :
Selective FAK inhibitor
target :
Focal Adhesion Kinase Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
storage :
Desiccate at RT
observed molecular weight :
284.01
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
FAK Inhibitor 14 is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. FAK Inhibitor 14 prevents FAK autophosphorylation at Y397 (IC50 = 1 M), promotes cell detachment and inhibits cell adhesion in vitro . FAK Inhibitor 14 exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo .
product keywords :
Selective FAK inhibitors inhibits Focal Adhesion Kinases Inhibitor14 Y15 NSC 677249 Focal Adhesion Kinase 3414,
extended description :
Selective FAK inhibitor
chemical name text :
1,2,4,5-Benzenetetramine tetrahydrochloride
formula :
C6H10N4.4HCl
formula text :
C6H10N4.4HCl
cas num :
4506-66-5
USD :
160
USD 2025 :
165 USD
product details :
Selective FAK inhibitor
alt names :
Y15,NSC 677249
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK