(Z)-4-Hydroxytamoxifen | Tocris Bioscience 3412/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(Z)-4-Hydroxytamoxifen

catalog :

3412/10

quantity :

10 mg (also 50 mg)

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Chatterjee S, Bhat V, Berdnikov A, Liu J, Zhang G, Buchel E, et al. Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth. iScience. 2019;19:388-401 pubmed publisher
Zhang W, Chronis C, Chen X, Zhang H, Spalinskas R, Pardo M, et al. The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. Cell Stem Cell. 2019;24:138-152.e8 pubmed publisher
Ito K, Park S, Katsyv I, Zhang W, De Angelis C, Schiff R, et al. PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells. NPJ Breast Cancer. 2017;3:45 pubmed publisher
Lee M, Koh D, Na H, Ka N, Kim S, Kim H, et al. MTA1 is a novel regulator of autophagy that induces tamoxifen resistance in breast cancer cells. Autophagy. 2017;: pubmed publisher
Candelaria N, Weldon R, Muthusamy S, Nguyen Vu T, Addanki S, Yoffou P, et al. Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells. PLoS ONE. 2015;10:e0145061 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3412

SKU :

3412/10

product name :

(Z)-4-Hydroxytamoxifen

Description :

Metabolite of tamoxifen (Cat. No. 0999)

target :

Estrogen and Related Receptor Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

387.51

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

( Z )-4-Hydroxytamoxifen is an estrogen receptor antagonist (IC50 = 27 M). ( Z )-4-Hydroxytamoxifen is a Tamoxifen (Cat. No. 0999) metabolite; that exhibits greater potency than the parent compound. ( Z )-4-Hydroxytamoxifen also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9. ( Z )-4-Hydroxytamoxifen binds to voltage-gated sodium channels, near the intracellular gate and inhibits the sodium current by delaying channel recovery from the inactivated state (IC50 values are 297 nM and 2.1 ?M for NavM and human Nav, respectively in HEK cells); this inhibition is independent of estrogen receptor modulation. Chemotherapeutic agent.

extended description :

Metabolite of tamoxifen (Cat. No. 0999)

chemical name text :

4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol

formula :

C 26 H 29 NO 2

formula text :

C26H29NO2

cas num :

68047-06-3

USD :

238 USD

product details :

Metabolite of tamoxifen (Cat. No. 0999)

alt names :

4-OH-TAM

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage