product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
R 715
catalog :
3407
quantity :
1 mg
price :
244 USD
more info or order :
citations: 6
Reference
Brailoiu E, McGuire M, Shuler S, Deliu E, Barr J, Abood M, et al. Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience. 2017;365:23-32 pubmed publisher
Falsetta M, Foster D, Woeller C, Pollock S, Bonham A, Haidaris C, et al. A Role for Bradykinin Signaling in Chronic Vulvar Pain. J Pain. 2016;17:1183-1197 pubmed publisher
Kawaguchi A, Sato M, Kimura M, Yamazaki T, Yamamoto H, Tazaki M, et al. Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. Front Cell Neurosci. 2015;9:229 pubmed publisher
Xu Y, Zhang Y, Cardell L. Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4. Am J Respir Cell Mol Biol. 2014;51:370-9 pubmed publisher
Pinheiro A, Paramos de Carvalho D, Certal M, Costa C, Magalhães Cardoso M, Ferreirinha F, et al. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal. 2013;11:70 pubmed publisher
Albert Weissenberger C, Stetter C, Meuth S, Göbel K, Bader M, SIREN A, et al. Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation. J Cereb Blood Flow Metab. 2012;32:1747-56 pubmed publisher
product information
brand :
Tocris
master code :
3407
SKU :
3407/1
product name :
R 715
description :
Potent and selective B1 antagonist
target :
Bradykinin Receptor Antagonists
category :
Peptides
unit size :
1 mg
observed molecular weight :
1140.35
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
Potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
catalog number base :
3407
product keywords :
Potent selective B1 antagonists Receptors Bradykinin R715 Bradykinin Receptors 3407,
extended description :
Potent and selective B1 antagonist
formula :
C 57 H 81 N 13 O 12
formula text :
C57H81N13O12
cas num :
185052-09-9
2020 USD :
234
2021 USD :
244 USD
storage :
Desiccate at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK