Vinorelbine ditartrate | Tocris Bioscience 3401 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Vinorelbine ditartrate

catalog :

3401

quantity :

10 mg (also 50 mg)

price :

157 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Mavroeidis L, Sheldon H, Briasoulis E, Marselos M, Pappas P, Harris A. Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition. Int J Oncol. 2015;47:455-64 pubmed publisher

product information

brand :

Tocris

master code :

3401

SKU :

3401/10

product name :

Vinorelbine ditartrate

description :

Selective mitotic microtubule antagonist

target :

Microtubule Binding Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

1079.1

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective mitotic microtubule antagonist that exhibits 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

catalog number base :

3401

product keywords :

Selective mitotic microtubule antagonists Tau Tubulin chemotherapeutics Navelbine Microtubules Mitosis 3401,

extended description :

Selective mitotic microtubule antagonist

chemical name text :

(2 ,3 ,4 ,5 ,12R,19 )-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl est

formula :

C 45 H 54 N 4 O 8 .2C 4 H 6 O 6

formula text :

C45H54N4O8.2C4H6O6

cas num :

125317-39-7

2020 USD :

152

2021 USD :

157 USD

alt names :

Navelbine

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage