Bicalutamide | Tocris Bioscience 3389 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bicalutamide

catalog :

3389

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Olokpa E, Bolden A, Stewart L. The Androgen Receptor Regulates PPAR? Expression and Activity in Human Prostate Cancer Cells. J Cell Physiol. 2016;231:2664-72 pubmed publisher
Gambara G, Desideri M, Stoppacciaro A, Padula F, De Cesaris P, Starace D, et al. TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo. J Cell Mol Med. 2015;19:327-39 pubmed publisher
Ivachtchenko A, Mitkin O, Kudan E, Rjahovsky A, Vorobiev A, Trifelenkov A, et al. Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment. J Cancer. 2014;5:133-42 pubmed publisher
Ishizaki F, Nishiyama T, Kawasaki T, Miyashiro Y, Hara N, Takizawa I, et al. Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer. Sci Rep. 2013;3:1528 pubmed publisher

product information

brand :

Tocris

master code :

3389

SKU :

3389/10

product name :

Bicalutamide

description :

Non-steroidal androgen receptor antagonist

target :

Androgen Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

430.37

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Orally active non-steroidal androgen receptor antagonist (IC50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo .

catalog number base :

3389

product keywords :

Non-steroidal Androgen receptor antagonists Dihydrotestosterone Receptors AstraZeneca ICI176,334 chemotherapeutics Casodex ICI 176,334 Androgen Receptor 3389,

extended description :

Non-steroidal androgen receptor antagonist

chemical name text :

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide

formula :

C 18 H 14 F 4 N 2 O 4 S

formula text :

C18H14F4N2O4S

cas num :

90357-06-5

2020 USD :

205

2021 USD :

210 USD

alt names :

Casodex, ICI 176,334

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage