Gedunin | Tocris Bioscience 3387 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Gedunin

catalog :

3387

quantity :

2 mg

price :

247 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Rizk M, El Sayed S, Terkawi M, Youssef M, El Said E, Elsayed G, et al. Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites. PLoS ONE. 2015;10:e0125276 pubmed publisher
Yadav V, Sung B, Prasad S, Kannappan R, Cho S, Liu M, et al. Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. J Mol Med (Berl). 2010;88:1243-53 pubmed publisher

product information

brand :

Tocris

master code :

3387

SKU :

3387/2

product name :

Gedunin

description :

Hsp90 inhibitor; exhibits anticancer and antimalarial activity

target :

HSP90 Inhibitors

category :

Small Molecules

unit size :

2 mg

main entrez gene id :

3320

purity :

98%

observed molecular weight :

482.57

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC50 values are 3.22, 8.84 and 16.8 M in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Decreases ovarian cancer cell proliferation in vitro and may enhance cisplatin -induced reduction in proliferation (CAT.No 3387). Also exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 M in parasite development and [3H]-hypoxanthine uptake assays respectively).

catalog number base :

3387

product keywords :

Hsp90 inhibitors inhibits anticancer antimalarial activity Heat Shock Protein 90 Hsp90 Antimalarials 3387,

extended description :

Hsp90 inhibitor; exhibits anticancer and antimalarial activity

chemical name text :

(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione

formula :

C 28 H 34 O 7

formula text :

C28H34O7

cas num :

2753-30-2

2020 USD :

247

2021 USD :

247 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage