Pugnac | Tocris Bioscience 3384/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Pugnac

catalog :

3384/10

quantity :

10 mg

price :

287 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Parween S, Varghese D, Ardah M, Prabakaran A, Mensah Brown E, Emerald B, et al. Higher O-GlcNAc Levels Are Associated with Defects in Progenitor Proliferation and Premature Neuronal Differentiation during in-Vitro Human Embryonic Cortical Neurogenesis. Front Cell Neurosci. 2017;11:415 pubmed publisher
Jo Y, Park N, Park S, Kim B, Shin J, Jo D, et al. O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity. Oncotarget. 2016;7:57186-57196 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3384

SKU :

3384/10

product name :

Pugnac

Description :

O-GlcNAcase and -hexosaminidase inhibitor

target :

Hydrolase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

353.33

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

( Z )-Pugnac is an O -GlcNAc- - N -acetylglucosaminidase ( O -GlcNAcase) and -hexosaminidase inhibitor (Ki values are 46 and 36 nM respectively) that increases O -GlcNAc levels ~ 2-fold in HT29 cells. Z -linked isomer is more potent than the E isomer.

extended description :

O-GlcNAcase and -hexosaminidase inhibitor

chemical name text :

O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate

formula :

C 15 H 19 N 3 O 7

formula text :

C15H19N3O7

cas num :

132489-69-1

USD :

287 USD

product details :

O-GlcNAcase and -hexosaminidase inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage