Benzamil | Tocris Bioscience 3380/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Benzamil

catalog :

3380/10

quantity :

10 mg (also 50 mg)

price :

96 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Mizuno T, Kinoshita S, Ito T, Maedera S, Kusuhara H. Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components. Sci Rep. 2019;9:1824 pubmed publisher
Singh P, Khatri I, Jha A, Pretto C, Spindler K, Arumugaswami V, et al. Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium. Sci Rep. 2018;8:11209 pubmed publisher
Panja D, Vedeler C, Schubert M. Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol. 2019;45:141-156 pubmed publisher
Zou L, Linck V, Zhai Y, Galarza Paez L, Li L, Yue Q, et al. Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport. J Biol Chem. 2018;293:1666-1675 pubmed publisher
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3380

SKU :

3380/10

product name :

Benzamil

Description :

NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative

target :

Na+/Ca2+ Exchanger Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

356.21

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Benzamil is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 M for inhibition of Ca2+-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).

extended description :

NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative

chemical name text :

N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride

formula :

C 13 H 14 ClN 7 O.HCl

formula text :

C13H14ClN7O.HCl

cas num :

161804-20-2

USD :

96 USD

product details :

NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage