chemical

Cortistatin 14

3374/1

1 mg

322 USD

3374

3374/1

Cortistatin 14

Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2

Additional Somatostatin Receptor Peptides

1 mg

Peptides

95%

Store at -20°C

1721.03

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Cortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst2, sst4, sst3, sst5 and sst1 receptors, respectively). Also a potent MRGPRX2 agonist (EC50 = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo .

Endogenous neuropeptide binds sst1 sst2 sst3 sst4 sst5 GHS-R1a Receptors Somatostatin Growth Hormone Secretagogue 1a Ghrelin Cortistatin14 neuropeptides mas-related g protein-coupled receptors MRGPRX2 Somatostatin Receptors Ghrelin Receptors Mas-related G Protein-Coupled Receptors 3374,

Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2

C81H113N19O19S2

C81H113N19O19S2

193829-96-8

309

322 USD

Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2