TCS OX2 29 | Tocris Bioscience 3371/50 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TCS OX2 29

catalog :

3371/50

quantity :

50 mg

price :

1017 USD

citations: 9

Reference
Bian K, Liu C, Wang Y, Xue Y, Chen L. Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian mice. Neurosci Lett. 2021;765:136291 pubmed publisher
Asadi S, Roohbakhsh A, Shamsizadeh A, Fereidoni M, Kordijaz E, Moghimi A. The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats. BMC Neurosci. 2018;19:49 pubmed publisher
Zhou J, Yuan F, Zhang Y, Li D. Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats. Neuropharmacology. 2015;99:481-90 pubmed publisher
Beig M, Horiuchi J, Dampney R, Carrive P. Both Ox1R and Ox2R orexin receptors contribute to the cardiorespiratory response evoked from the perifornical hypothalamus. Clin Exp Pharmacol Physiol. 2015;42:1059-67 pubmed publisher
Shu Q, Hu Z, Huang C, Yu X, Fan H, Yang J, et al. Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals. PLoS ONE. 2014;9:e95259 pubmed publisher
Brown R, Khoo S, Lawrence A. Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats. Int J Neuropsychopharmacol. 2013;16:2067-79 pubmed publisher
Plaza Zabala A, Flores A, Martín García E, Saravia R, Maldonado R, Berrendero F. A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior. Neuropsychopharmacology. 2013;38:1724-36 pubmed publisher
Urbańska A, Sokołowska P, Woldan Tambor A, Biegańska K, Brix B, Jöhren O, et al. Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures. J Mol Neurosci. 2012;46:10-7 pubmed publisher
Huang S, Dai Y, Lee Y, Chiou L, Hwang L. Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors. J Pharmacol Exp Ther. 2010;334:522-9 pubmed publisher

product information

brand :

Tocris

master code :

3371

SKU :

3371/50

product name :

TCS OX2 29

description :

Potent and selective OX2 antagonist

target :

OX2 Receptor Antagonists

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

433.97

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TCS OX2 29 is a potent and selective OX2 receptor antagonist (IC50 = 40 nM). Displays 250-fold selectivity for OX2 over OX1 and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.

catalog number base :

3371

extended description :

Potent and selective OX2 antagonist

chemical name text :

(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride

formula :

C 23 H 31 N 3 O 3 .HCl

formula text :

C23H31N3O3.HCl

cas num :

1610882-30-8

USD 2021 :

952

USD 2022 :

1017 USD

product details :

Potent and selective OX2 antagonist

storage :

Desiccate at +4°C