AC 55541 | Tocris Bioscience 3369 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AC 55541

catalog :

3369

quantity :

10 mg (also 50 mg)

price :

229 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Rabelo Melo F, Santosh Martin S, Sommerhoff C, Pejler G. Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression. Cell Death Dis. 2019;10:659 pubmed publisher
Shi Y, Hung S, Rocha G, Lin S, Linares G, Staats K, et al. Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. JCI Insight. 2019;5: pubmed publisher
Shi H, Liu C, Ding L, Zheng Y, Fei X, Lu L, et al. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. World J Gastroenterol. 2015;21:4852-63 pubmed publisher
White M, Galvis Carvajal E, Gomer R. A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p. J Immunol. 2015;194:142-50 pubmed publisher
Alkhani H, Ase A, Grant R, O donnell D, Groschner K, Séguéla P. Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Mol Pain. 2014;10:43 pubmed publisher
Tripathi T, Abdi M, Alizadeh H. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2014;55:3912-21 pubmed publisher

product information

brand :

Tocris

master code :

3369

SKU :

3369/10

product name :

AC 55541

description :

Potent and selective PAR2 agonist

target :

Protease-Activated Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

518.36

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo .

catalog number base :

3369

product keywords :

Potent selective PAR2 agonists Receptors Protease-Activated proteinase-activated AC55541 Protease-Activated Receptors 3369,

extended description :

Potent and selective PAR2 agonist

chemical name text :

(2E)-2-[1-(3-Bromophenyl)ethylidene] -(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide

formula :

C 25 H 20 BrN 5 O 3

formula text :

C25H20BrN5O3

cas num :

916170-19-9

2020 USD :

222

2021 USD :

229 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage