AT 101 | Tocris Bioscience 3367/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AT 101

catalog :

3367/10

quantity :

10 mg (also 50 mg)

price :

229 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Chen C, Dienhart J, Bolton E. Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. PLoS ONE. 2016;11:e0156145 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3367

SKU :

3367/10

product name :

AT 101

Description :

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

target :

Additional Bcl-2 Family Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

518.56

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AT 101 is a R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo .

extended description :

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

chemical name text :

(-)-1,1 ,6,6 ,7,7 -Hexahydroxy-3,3 -dimethyl-5,5 -bis(1-methylethyl)-[2,2 -binaphthalene]-8,8 -dicarboxaldehyde

formula :

C 30 H 30 O 8

formula text :

C30H30O8

cas num :

90141-22-3

USD :

229 USD

product details :

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage