BIX 01294 | Tocris Bioscience 3364 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIX 01294

catalog :

3364

quantity :

10 mg (also 50 mg)

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Bellamy J, Szemes M, Melegh Z, Dallosso A, Kollareddy M, Catchpoole D, et al. Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma. Front Oncol. 2020;10:818 pubmed publisher
Li H, Petersen S, García Mariscal A, Brakebusch C. Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation. Cancer Res. 2019;79:2167-2181 pubmed publisher
Li H, Yao Q, Mariscal A, Wu X, Hulse J, Pedersen E, et al. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nat Commun. 2018;9:1420 pubmed publisher
Plews J, Li J, Jones M, Moore H, Mason C, Andrews P, et al. Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach. PLoS ONE. 2010;5:e14397 pubmed publisher

product information

brand :

Tocris

master code :

3364

SKU :

3364/10

product name :

BIX 01294

description :

GLP and G9a inhibitor

target :

Lysine Methyltransferase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

600.02

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GLP and G9a histone lysine methyltransferase inhibitor (IC50 values are 0.7 and 1.7 M respectively) that displays no activity at other histone methyltransferases up to 37 M. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro . Also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3 (IC50 values are 40 - 112 M). Restores metabolic and antiviral function in exhausted CD8+ T cells from patients with chronic HCV infection.

catalog number base :

3364

product keywords :

G9a-like protein and G9a histone lysine methyltransferases HMTases inhibitors inhibits BIX01294 stem cells epigenetics oncoproteins NSD1 NSD2 NSD3 CD8+ T cells exhaustion exhausted viral infections Stem Cell Reprogramming Lysine Methyltransferases G9a/GLP 3364,

extended description :

GLP and G9a inhibitor

chemical name text :

2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride

formula :

C 28 H 38 N 6 O 2 .3HCl

formula text :

C28H38N6O2.3HCl

cas num :

1392399-03-9

2020 USD :

203

2021 USD :

212 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage