MG 101 | Tocris Bioscience 3358 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MG 101

catalog :

3358

quantity :

5 mg

price :

115 USD

citations: 1

Reference
Ishizuka E, Filgueiras L, Rios F, Serezani C, Jancar S. PAFR activation of NF-?B p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages. Sci Rep. 2016;6:32092 pubmed publisher

product information

brand :

Tocris

master code :

3358

SKU :

3358/5

product name :

MG 101

description :

Calpain inhibitor; activates p53-dependent apoptosis

target :

Calpain Inhibitors

category :

Small Molecules

unit size :

5 mg

observed molecular weight :

383.53

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Calpain inhibitor (IC50 = 0.09 M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro . Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.

catalog number base :

3358

product keywords :

Calpain inhibitors inhibits Proteinases Proteases MG101 Calpain inhibitor-1 Calpains Calcium-Sensitive Proteases 3358,

extended description :

Calpain inhibitor; activates p53-dependent apoptosis

chemical name text :

N-Acetyl-L-leucine-L-leucine-L-norleucinal

formula :

C 20 H 37 N 3 O 4

formula text :

C20H37N3O4

cas num :

110044-82-1

2020 USD :

112

2021 USD :

115 USD

alt names :

Calpain inhibitor-1

storage :

Store at -20°C