PF 429242 dihydrochloride | Tocris Bioscience 3354/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 429242 dihydrochloride

catalog :

3354/10

quantity :

10 mg (also 50 mg)

price :

334 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Tien C, Chen C, Lin W, Liu C, Liu K, Hsiao M, et al. Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD. Aging (Albany NY). 2019;11:4654-4671 pubmed publisher
Flint M, Chatterjee P, Lin D, McMullan L, Shrivastava Ranjan P, Bergeron E, et al. A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus. Nat Commun. 2019;10:285 pubmed publisher
Scott C, Vossio S, Rougemont J, Gruenberg J. TFAP2 transcription factors are regulators of lipid droplet biogenesis. elife. 2018;7: pubmed publisher
Uchida L, Urata S, Ulanday G, Takamatsu Y, Yasuda J, Morita K, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016;8: pubmed publisher
Urata S, Weyer J, Storm N, Miyazaki Y, van Vuren P, Paweska J, et al. Analysis of Assembly and Budding of Lujo Virus. J Virol. 2015;90:3257-61 pubmed publisher
Kleinfelter L, Jangra R, Jae L, Herbert A, Mittler E, Stiles K, et al. Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion. MBio. 2015;6:e00801 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3354

SKU :

3354/10

product name :

PF 429242 dihydrochloride

Description :

Competitive inhibitor of SREBP site 1 protease

target :

SREBP Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

482.49

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 429242 dihydrochloride is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 M). Selective for site 1 protease against a panel of serine proteases. Inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 M). Also displays antiviral activity. Cell permeable.

extended description :

Competitive inhibitor of SREBP site 1 protease

chemical name text :

4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide dihydrochloride

formula :

C 25 H 35 N 3 O 2 .2HCl

formula text :

C25H35N3O2.2HCl

cas num :

2248666-66-0

USD :

334 USD

product details :

Competitive inhibitor of SREBP site 1 protease

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage