10Panx | Tocris Bioscience 3348/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

10Panx

catalog :

3348/1

quantity :

1 mg

price :

177 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Hudson G, Flannigan K, Venu V, Alston L, Sandall C, MacDonald J, et al. Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation. J Pharmacol Exp Ther. 2019;370:44-53 pubmed publisher
Chen W, Zhu S, Wang Y, Li J, Qiang X, Zhao X, et al. Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis. Sci Rep. 2019;9:160 pubmed publisher
Janks L, Sharma C, Egan T. A central role for P2X7 receptors in human microglia. J Neuroinflammation. 2018;15:325 pubmed publisher
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
Boucher J, Simonneau C, Denet G, Clarhaut J, Balandre A, Mesnil M, et al. Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis. Int J Mol Sci. 2018;19: pubmed publisher
Barría I, Güiza J, Cifuentes F, Zamorano P, Saez J, Gonzalez J, et al. Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. Am J Trop Med Hyg. 2018;98:105-112 pubmed publisher
Albalawi F, Lu W, Beckel J, Lim J, McCaughey S, Mitchell C. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci. 2017;11:227 pubmed publisher
Adamczyk M, Griffiths R, Dewitt S, Knauper V, Aeschlimann D. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. J Cell Sci. 2015;128:4615-28 pubmed publisher
Kowal J, Haanes K, Christensen N, Novak I. Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells. Cell Commun Signal. 2015;13:28 pubmed publisher
Melhorn M, Brodsky A, Estanislau J, Khoory J, Illigens B, Hamachi I, et al. CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process. J Biol Chem. 2013;288:31139-53 pubmed publisher
Manohar M, Hirsh M, Chen Y, Woehrle T, Karande A, Junger W. ATP release and autocrine signaling through P2X4 receptors regulate ?? T cell activation. J Leukoc Biol. 2012;92:787-94 pubmed publisher
Fritsche G, Nairz M, Libby S, Fang F, Weiss G. Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression. J Leukoc Biol. 2012;92:353-9 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3348

SKU :

3348/1

product name :

10Panx

description :

Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions

target :

Gap Channel Blockers

unit size :

1 mg

category :

Peptides

purity :

95%

storage :

Store at -20°C

observed molecular weight :

1242.37

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

10Panx is a panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1 release and caspase-1 activation without altering membrane current in macrophages in vitro . Also blocks activation of NMDA receptor secondary currents (I2nd) by 70%.

product keywords :

Panx-1 mimetic inhibitory peptide blocks pannexin-1 gap junctions Connexins Channels modulators Gap Channels 3348,

extended description :

Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions

formula :

C58H79N15O16

formula text :

C58H79N15O16

cas num :

955091-53-9

USD :

171

USD 2025 :

177 USD

product details :

Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions

more info or order :

Tocris Bioscience product webpage