L-798,106 | Tocris Bioscience 3342 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-798,106

catalog :

3342

quantity :

10 mg (also 50 mg)

price :

223 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Perkins D, Richard K, Hansen A, Lai W, Nallar S, Koller B, et al. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat Immunol. 2018;19:1309-1318 pubmed publisher
Ye Y, Vattai A, Ditsch N, Kuhn C, Rahmeh M, Mahner S, et al. Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses. Endocr Connect. 2018;7:749-761 pubmed publisher
Zhu J, Trillsch F, Mayr D, Kuhn C, Rahmeh M, Hofmann S, et al. Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients. Oncotarget. 2018;9:982-994 pubmed publisher
Yang G, Ren Z, Mei Y. Exposure to 50 Hz magnetic field modulates GABAA currents in cerebellar granule neurons through an EP receptor-mediated PKC pathway. J Cell Mol Med. 2015;19:2413-22 pubmed publisher
Fernández Galilea M, Perez Matute P, Prieto Hontoria P, Martinez J, Moreno Aliaga M. Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. J Lipid Res. 2012;53:2296-306 pubmed publisher
Tunaru S, Althoff T, Nusing R, Diener M, Offermanns S. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A. 2012;109:9179-84 pubmed publisher
Chia E, Kagota S, Wijekoon E, McGuire J. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol. 2011;11:10 pubmed publisher

product information

brand :

Tocris

master code :

3342

SKU :

3342/10

product name :

L-798,106

description :

Potent and highly selective EP3 antagonist

target :

Prostanoid Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

536.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, 5000 and 5000 nM at EP3, EP4, EP1 and EP2 respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo .

catalog number base :

3342

product keywords :

Potent selective EP3 antagonists Receptors Prostanoid prostaglandins prostacyclins eicosanoids L798106 Prostanoid Receptors 3342,

extended description :

Potent and highly selective EP3 antagonist

chemical name text :

N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide

formula :

C 27 H 22 BrNO 4 S

formula text :

C27H22BrNO4S

cas num :

244101-02-8

2020 USD :

218

2021 USD :

223 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage