L-798,106 | Tocris Bioscience 3342/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-798,106

catalog :

3342/10

quantity :

10 mg (also 50 mg)

price :

281 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Perkins D, Richard K, Hansen A, Lai W, Nallar S, Koller B, et al. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat Immunol. 2018;19:1309-1318 pubmed publisher
Ye Y, Vattai A, Ditsch N, Kuhn C, Rahmeh M, Mahner S, et al. Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses. Endocr Connect. 2018;7:749-761 pubmed publisher
Zhu J, Trillsch F, Mayr D, Kuhn C, Rahmeh M, Hofmann S, et al. Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients. Oncotarget. 2018;9:982-994 pubmed publisher
Flórez Grau G, Cabezón R, Borgman K, España C, Lozano J, Garcia Parajo M, et al. Up-regulation of EP2 and EP3 receptors in human tolerogenic dendritic cells boosts the immunosuppressive activity of PGE2. J Leukoc Biol. 2017;102:881-895 pubmed publisher
Yang G, Ren Z, Mei Y. Exposure to 50 Hz magnetic field modulates GABAA currents in cerebellar granule neurons through an EP receptor-mediated PKC pathway. J Cell Mol Med. 2015;19:2413-22 pubmed publisher
Yuan Z, Mehta H, Mohammed K, Nasreen N, Roman R, Brantly M, et al. TREM-1 is induced in tumor associated macrophages by cyclo-oxygenase pathway in human non-small cell lung cancer. PLoS ONE. 2014;9:e94241 pubmed publisher
Fernández Galilea M, Perez Matute P, Prieto Hontoria P, Martinez J, Moreno Aliaga M. Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. J Lipid Res. 2012;53:2296-306 pubmed publisher
Ylostalo J, Bartosh T, Coble K, Prockop D. Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells. 2012;30:2283-96 pubmed publisher
Tunaru S, Althoff T, Nusing R, Diener M, Offermanns S. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A. 2012;109:9179-84 pubmed publisher
Chia E, Kagota S, Wijekoon E, McGuire J. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol. 2011;11:10 pubmed publisher

product information

brand :

Tocris

catalog number base :

3342

SKU :

3342/10

product name :

L-798,106

units size :

10 mg (also 50 mg)

description :

Potent and highly selective EP3 antagonist

target :

Prostanoid Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

536.44

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L-798,106 is a potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, 5000 and 5000 nM at EP3, EP4, EP1 and EP2 respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo .

top caption :

Potent and highly selective EP3 antagonist

extended description :

Potent and highly selective EP3 antagonist

chemical name text :

N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide

formula :

C27H22BrNO4S

formula text :

C27H22BrNO4S

cas num :

244101-02-8

USD :

281 USD

product details :

Potent and highly selective EP3 antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage