JK 184 | Tocris Bioscience 3341 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JK 184

catalog :

3341

quantity :

25 mg

price :

288 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Oladapo H, Tarpley M, Sauer S, Addo K, Ingram S, Strepay D, et al. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett. 2017;411:136-149 pubmed publisher

product information

brand :

Tocris

master code :

3341

SKU :

3341/25

product name :

JK 184

description :

Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway

target :

Dehydrogenase Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

99%

observed molecular weight :

350.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo . Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro .

catalog number base :

3341

product keywords :

Alcohol dehydrogenase 7 inhibitors inhibits downstream Hh signaling pathway Signalling Hedgehog Gli JK184 stem cells Hedgehog Signaling Alcohol Dehydrogenase Stem Cell Signaling 3341,

extended description :

Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway

chemical name text :

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

formula :

C 19 H 18 N 4 OS

formula text :

C19H18N4OS

cas num :

315703-52-7

2020 USD :

288

2021 USD :

288 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage