JK 184 | Tocris Bioscience 3341/5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JK 184

catalog :

3341/5

quantity :

5 mg (also 25 mg)

price :

76 USD

citations: 1

Reference
Oladapo H, Tarpley M, Sauer S, Addo K, Ingram S, Strepay D, et al. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett. 2017;411:136-149 pubmed publisher

product information

brand :

Tocris

SKU :

3341/5

product name :

JK 184

unit sizes :

5 mg (also 25 mg)

description :

Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway

target :

Dehydrogenase Inhibitors

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

350.44

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo . Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro .

catalog number base :

3341

extended description :

Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway

chemical name text :

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

formula :

C 19 H 18 N 4 OS

formula text :

C19H18N4OS

cas num :

315703-52-7

USD :

76 USD

default size :

TRUE

product details :

Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway