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company name :
Tocris Bioscience
product type :
chemical
product name :
A 769662
catalog :
3336/10
quantity :
10 mg (also 50 mg)
price :
281 USD
more info or order :
citations: 31
Reference
Ahwazi D, Neopane K, Markby G, Kopietz F, Ovens A, Dall M, et al. Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965. Biochem J. 2021;478:2977-2997 pubmed publisher
Paige C, Mejia G, Dussor G, PRICE T. AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo. Neurobiol Pain. 2019;5: pubmed publisher
Lee J, Lee J, Cho Y. Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency. J Clin Med. 2018;7: pubmed publisher
Gélinas R, Mailleux F, Dontaine J, Bultot L, Demeulder B, Ginion A, et al. AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation. Nat Commun. 2018;9:374 pubmed publisher
Huang Y, Smith C, Chen G, Sharma B, Miner A, Barbee R, et al. The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation. Front Pharmacol. 2017;8:756 pubmed publisher
Hamann J, Surcel A, Chen R, Teragawa C, Albeck J, Robinson D, et al. Entosis Is Induced by Glucose Starvation. Cell Rep. 2017;20:201-210 pubmed publisher
Dai S, Dulcey A, Hu X, Wassif C, Porter F, Austin C, et al. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy. 2017;13:1435-1451 pubmed publisher
Zaborska K, Edwards G, Austin C, Wareing M. The Role of O-GlcNAcylation in Perivascular Adipose Tissue Dysfunction of Offspring of High-Fat Diet-Fed Rats. J Vasc Res. 2017;54:79-91 pubmed publisher
Vlachaki Walker J, Robb J, Cruz A, Malhi A, Weightman Potter P, Ashford M, et al. AMP-activated protein kinase (AMPK) activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner. Diabetes Obes Metab. 2017;19:997-1005 pubmed publisher
Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, et al. Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE. J Biol Chem. 2017;292:64-79 pubmed publisher
Muller Durovic B, Lanna A, Covre L, Mills R, Henson S, Akbar A. Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase. J Immunol. 2016;197:2891-2899 pubmed publisher
Cameron A, Morrison V, Levin D, Mohan M, Forteath C, Beall C, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016;119:652-65 pubmed publisher
Walter C, Clemens L, Müller A, Fallier Becker P, Proikas Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed publisher
Saric A, Hipolito V, Kay J, Canton J, Antonescu C, Botelho R. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells. Mol Biol Cell. 2016;27:321-33 pubmed publisher
Hwang J, Kim Y, Noh J, Choi D, Kim K, Lee C. Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury. Mol Cells. 2015;38:843-50 pubmed publisher
Peart T, Ramos Valdes Y, Correa R, Fazio E, Bertrand M, McGee J, et al. Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids. Oncotarget. 2015;6:22424-38 pubmed
Mo J, Meng Z, Kim Y, Park H, Hansen C, Kim S, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015;17:500-10 pubmed publisher
Kenney J, Sorokina O, Genheden M, Sorokin A, Armstrong J, Proud C. Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity. J Neurosci. 2015;35:3034-47 pubmed publisher
López Cotarelo P, Escribano Díaz C, González Bethencourt I, Gómez Moreira C, Deguiz M, Torres Bacete J, et al. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. J Biol Chem. 2015;290:827-40 pubmed publisher
Weikel K, Cacicedo J, Ruderman N, Ido Y. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. Am J Physiol Cell Physiol. 2015;308:C249-63 pubmed publisher
Lanna A, Henson S, Escors D, Akbar A. The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat Immunol. 2014;15:965-72 pubmed publisher
Jenkins Y, Sun T, Markovtsov V, Foretz M, Li W, Nguyen H, et al. AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes. PLoS ONE. 2013;8:e81870 pubmed publisher
Melemedjian O, Mejia G, Lepow T, Zoph O, Price T. Bidirectional regulation of P body formation mediated by eIF4F complex formation in sensory neurons. Neurosci Lett. 2014;563:169-74 pubmed publisher
Wu N, Zheng B, SHAYWITZ A, Dagon Y, Tower C, Bellinger G, et al. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell. 2013;49:1167-75 pubmed publisher
Lo B, Strasser G, Sagolla M, Austin C, Junttila M, Mellman I. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways. J Cell Biol. 2012;199:1117-30 pubmed publisher
Mack H, Zheng B, Asara J, Thomas S. AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization. Autophagy. 2012;8:1197-214 pubmed publisher
Alvarez Y, Rodriguez M, Municio C, Hugo E, Alonso S, Ibarrola N, et al. Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells. J Biol Chem. 2012;287:35689-701 pubmed publisher
Zhang Y, Qiu J, Wang X, Zhang Y, Xia M. AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. Arterioscler Thromb Vasc Biol. 2011;31:2897-908 pubmed publisher
Bumpus N, Johnson E. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated pro. J Pharmacol Exp Ther. 2011;339:886-95 pubmed publisher
Paiva M, Rutter Locher Z, Goncalves L, Providencia L, Davidson S, Yellon D, et al. Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury. Am J Physiol Heart Circ Physiol. 2011;300:H2123-34 pubmed publisher
Terkeltaub R, Yang B, Lotz M, Liu Bryan R. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1? and tumor necrosis factor ?. Arthritis Rheum. 2011;63:1928-37 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3336
SKU :
3336/10
product name :
A 769662
description :
Potent AMPK activator
target :
AMPK Activators
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at +4°C
observed molecular weight :
360.39
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
A 769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 M) that displays selectivity towards 1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC50 = 3.2 M) and decreases plasma glucose and triglyceride levels in vivo . Also inhibits proliferation of mesenchymal stem cells, and impedes reprogramming of mouse embryonic fibroblasts to iPSCs. Activates autophagy.
product keywords :
Potent AMPK activators AMP-Activated Protein Kinases A769662 AMPK Enzyme Substrates/ Activators Stem Cell Proliferation Autophagy 3336,
extended description :
Potent AMPK activator
chemical name text :
6,7-Dihydro-4-hydroxy-3-(2 -hydroxy[1,1 -biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
formula :
C20H12N2O3S
formula text :
C20H12N2O3S
cas num :
844499-71-4
USD :
269
USD 2025 :
281 USD
product details :
Potent AMPK activator
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK