NDT 9513727 | Tocris Bioscience 3333 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NDT 9513727

catalog :

3333

quantity :

10 mg (also 50 mg)

price :

278 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Liu H, Kim H, Deepak R, Wang L, Chung K, Fan H, et al. Orthosteric and allosteric action of the C5a receptor antagonists. Nat Struct Mol Biol. 2018;25:472-481 pubmed publisher

product information

brand :

Tocris

master code :

3333

SKU :

3333/10

product name :

NDT 9513727

description :

Potent, selective human C5a receptor negative allosteric modulator (NAM)

target :

Complement Signaling inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

573.68

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent C5a receptor (C5aR) negative allosteric modulator (NAM) (IC50 = 11.6 nM); selective for human C5aR (IC50 values for rat and mouse C5aR are 10 M). Exhibits inverse agonist pharmacokinetics. Blocks degranulation response in C5a-stimulated U937 cells (IC50 = 7.1 nM). Exhibits selectivity for primate and gerbil receptor over other species. Orally bioavailable.

catalog number base :

3333

product keywords :

potent complement C5a receptor C5aR antagonists competitive inverse agonists human orally active NDT9513727 NAM negative allostreic modulators Complement 3333,

extended description :

Potent, selective human C5a receptor negative allosteric modulator (NAM)

chemical name text :

N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine

formula :

C 36 H 35 N 3 O 4

formula text :

C36H35N3O4

cas num :

439571-48-9

2020 USD :

278

2021 USD :

278 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage