CID 755673 | Tocris Bioscience 3327 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CID 755673

catalog :

3327

quantity :

10 mg

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Zhang Z, Meszaros G, He W, Xu Y, de Fatima Magliarelli H, Mailly L, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017;214:2671-2693 pubmed publisher
Chen Y, Kan W. Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells. Biochim Biophys Acta. 2015;1853:2662-75 pubmed publisher
Xu X, Gera N, Li H, Yun M, Zhang L, Wang Y, et al. GPCR-mediated PLCÎ²Î³/PKCÎ²/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis. Mol Biol Cell. 2015;26:874-86 pubmed publisher
Rezaee F, DeSando S, Ivanov A, Chapman T, Knowlden S, Beck L, et al. Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption. J Virol. 2013;87:11088-95 pubmed publisher
Kienzle C, Eisler S, Villeneuve J, Brummer T, Olayioye M, Hausser A. PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Mol Biol Cell. 2013;24:222-33 pubmed publisher
Subathra M, Qureshi A, Luberto C. Sphingomyelin synthases regulate protein trafficking and secretion. PLoS ONE. 2011;6:e23644 pubmed publisher
Spratley S, Bastea L, Döppler H, Mizuno K, Storz P. Protein kinase D regulates cofilin activity through p21-activated kinase 4. J Biol Chem. 2011;286:34254-61 pubmed publisher
Bhattacharya S, Zheng H, Tzimas C, Carroll M, Baker D, Fuchs S. Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFN? via accelerating the degradation of its receptor. Blood. 2011;118:4179-87 pubmed publisher
Dokas L, Malone A, Williams F, Nauli S, Messer W. Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells. Neuropharmacology. 2011;61:12-24 pubmed publisher
Qureshi A, Subathra M, Grey A, Schey K, Del Poeta M, Luberto C. Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans. PLoS ONE. 2010;5:e15587 pubmed publisher
Zheng H, Qian J, Varghese B, Baker D, FUCHS S. Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2. Mol Cell Biol. 2011;31:710-20 pubmed publisher
Torres Marquez E, Sinnett Smith J, Guha S, Kui R, Waldron R, Rey O, et al. CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway. Biochem Biophys Res Commun. 2010;391:63-8 pubmed publisher

product information

brand :

Tocris

master code :

3327

SKU :

3327/10

product name :

CID 755673

description :

Selective protein kinase D inhibitor

target :

Protein Kinase D Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

217.22

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, 10, 15.3, 20.3, 40.5 and 50 M at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKII and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro .

catalog number base :

3327

product keywords :

Selective protein kinases D inhibitors inhibits PKD CID755673 Protein Kinase D 3327,

extended description :

Selective protein kinase D inhibitor

chemical name text :

2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one

formula :

C 12 H 11 NO 3

formula text :

C12H11NO3

cas num :

521937-07-5

2020 USD :

253

2021 USD :

264 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage