CID 755673 | Tocris Bioscience 3327/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CID 755673

catalog :

3327/10

quantity :

10 mg

price :

296 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Zhang Z, Meszaros G, He W, Xu Y, de Fatima Magliarelli H, Mailly L, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017;214:2671-2693 pubmed publisher
Chen Y, Kan W. Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells. Biochim Biophys Acta. 2015;1853:2662-75 pubmed publisher
Xu X, Gera N, Li H, Yun M, Zhang L, Wang Y, et al. GPCR-mediated PLCÎ²Î³/PKCÎ²/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis. Mol Biol Cell. 2015;26:874-86 pubmed publisher
Rezaee F, DeSando S, Ivanov A, Chapman T, Knowlden S, Beck L, et al. Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption. J Virol. 2013;87:11088-95 pubmed publisher
Kienzle C, Eisler S, Villeneuve J, Brummer T, Olayioye M, Hausser A. PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Mol Biol Cell. 2013;24:222-33 pubmed publisher
Subathra M, Qureshi A, Luberto C. Sphingomyelin synthases regulate protein trafficking and secretion. PLoS ONE. 2011;6:e23644 pubmed publisher
Spratley S, Bastea L, Döppler H, Mizuno K, Storz P. Protein kinase D regulates cofilin activity through p21-activated kinase 4. J Biol Chem. 2011;286:34254-61 pubmed publisher
Bhattacharya S, Zheng H, Tzimas C, Carroll M, Baker D, Fuchs S. Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFN? via accelerating the degradation of its receptor. Blood. 2011;118:4179-87 pubmed publisher
Dokas L, Malone A, Williams F, Nauli S, Messer W. Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells. Neuropharmacology. 2011;61:12-24 pubmed publisher
Qureshi A, Subathra M, Grey A, Schey K, Del Poeta M, Luberto C. Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans. PLoS ONE. 2010;5:e15587 pubmed publisher
Zheng H, Qian J, Varghese B, Baker D, FUCHS S. Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2. Mol Cell Biol. 2011;31:710-20 pubmed publisher
Torres Marquez E, Sinnett Smith J, Guha S, Kui R, Waldron R, Rey O, et al. CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway. Biochem Biophys Res Commun. 2010;391:63-8 pubmed publisher

image

image 1 :

Cat.No. 3327 - CID 755673 C12H11NO3 CAS No. 521937-07-5

product information

brand :

Tocris

catalog number base :

3327

SKU :

3327/10

product name :

CID 755673

units size :

10 mg

description :

Selective protein kinase D inhibitor

target :

Protein Kinase D Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

217.22

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

CID 755673 is a selective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, 10, 15.3, 20.3, 40.5 and 50 M at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKII and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro .

top caption :

Selective protein kinase D inhibitor

extended description :

Selective protein kinase D inhibitor

chemical name text :

2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one

formula :

C12H11NO3

formula text :

C12H11NO3

cas num :

521937-07-5

USD :

296 USD

product details :

Selective protein kinase D inhibitor

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage