QS 11 | Tocris Bioscience 3324/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

QS 11

catalog :

3324/10

quantity :

10 mg (also 50 mg)

price :

261 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Gowda P, Patrick S, Singh A, Sheikh T, Sen E. Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression. Mol Cell Biol. 2018;38: pubmed publisher
Wu J, Li W, Lin C, Chen Y, Cheng C, Sun S, et al. Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles. Sci Rep. 2016;6:29418 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3324

SKU :

3324/10

product name :

QS 11

Description :

ARFGAP1 inhibitor; modulates Wnt/ -catenin signaling

target :

ARF GTPase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

567.68

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/ -catenin signaling pathway to upregulate -catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.

extended description :

ARFGAP1 inhibitor; modulates Wnt/ -catenin signaling

chemical name text :

(2S)-2-[2-(Indan-5-yloxy)-9-(1,1 -biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol

formula :

C 36 H 33 N 5 O 2

formula text :

C36H33N5O2

cas num :

944328-88-5

USD :

261 USD

product details :

ARFGAP1 inhibitor; modulates Wnt/ -catenin signaling

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage