AZ 10606120 dihydrochloride | Tocris Bioscience 3323/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZ 10606120 dihydrochloride

catalog :

3323/10

quantity :

10 mg (also 50 mg)

price :

251 USD

more info or order :

Tocris Bioscience product webpage

citations: 17

Reference
Palygin O, Ilatovskaya D, Levchenko V, Klemens C, Dissanayake L, Williams A, et al. Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic Signal. 2018;14:485-497 pubmed publisher
Allsopp R, Dayl S, Schmid R, Evans R. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Sci Rep. 2017;7:725 pubmed publisher
Russo H, Rathkey J, Boyd Tressler A, Katsnelson M, Abbott D, Dubyak G. Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol. 2016;197:1353-67 pubmed publisher
Karmakar M, Katsnelson M, Dubyak G, Pearlman E. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1Î² secretion in response to ATP. Nat Commun. 2016;7:10555 pubmed publisher
Giannuzzo A, Pedersen S, Novak I. The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells. Mol Cancer. 2015;14:203 pubmed publisher
Lioi A, Ferrari B, Dubyak G, Weinberg A, Sieg S. Human β Defensin-3 Increases CD86 Expression on Monocytes by Activating the ATP-Gated Channel P2X7. J Immunol. 2015;195:4438-45 pubmed publisher
Kowal J, Haanes K, Christensen N, Novak I. Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells. Cell Commun Signal. 2015;13:28 pubmed publisher
Helliwell R, ShioukHuey C, Dhuna K, Molero J, Ye J, Xue C, et al. Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors. Br J Pharmacol. 2015;172:3326-40 pubmed publisher
Adinolfi E, Capece M, Franceschini A, Falzoni S, Giuliani A, Rotondo A, et al. Accelerated tumor progression in mice lacking the ATP receptor P2X7. Cancer Res. 2015;75:635-44 pubmed publisher
Martin B, Wang C, Willette Brown J, Herjan T, Gulen M, Zhou H, et al. IKK? negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014;5:4977 pubmed publisher
Kaiser M, Sobottka H, Fischer W, Schaefer M, Nörenberg W. Tanshinone II A sulfonate, but not tanshinone II A, acts as potent negative allosteric modulator of the human purinergic receptor P2X7. J Pharmacol Exp Ther. 2014;350:531-42 pubmed publisher
Bhaskaracharya A, Dao Ung P, Jalilian I, Spildrejorde M, Skarratt K, Fuller S, et al. Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. PLoS ONE. 2014;9:e93058 pubmed publisher
Fischer W, Urban N, Immig K, Franke H, Schaefer M. Natural compounds with P2X7 receptor-modulating properties. Purinergic Signal. 2014;10:313-26 pubmed publisher
Gadeock S, Pupovac A, Sluyter V, Spildrejorde M, Sluyter R. P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells. Purinergic Signal. 2012;8:669-76 pubmed publisher
Nörenberg W, Sobottka H, Hempel C, Plötz T, Fischer W, Schmalzing G, et al. Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol. 2012;167:48-66 pubmed publisher
Heinrich A, Andó R, Turi G, Rozsa B, Sperlagh B. K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. Br J Pharmacol. 2012;167:1003-20 pubmed publisher
Hracsko Z, Baranyi M, Csölle C, Gölöncsér F, Madarász E, Kittel A, et al. Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease. Mol Neurodegener. 2011;6:28 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3323

SKU :

3323/10

product name :

AZ 10606120 dihydrochloride

description :

Potent P2X7 antagonist

target :

P2X Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at RT

observed molecular weight :

495.48

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZ 10606120 dihydrochloride is a potent P2X7 receptor antagonist (KD values are 1.4 and 19 nM at human and rat P2X7 receptors respectively). Binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Inhibits tumor growth and displays antiangiogenic effects in mice.

product keywords :

Potent P2X7 receptor antagonists Receptors Purinergic purinoceptors AZ10606120 dihydrochloride AstraZeneca P2X Receptors 3323,

extended description :

Potent P2X7 antagonist

chemical name text :

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride

formula :

C25H34N4O2.2HCl

formula text :

C25H34N4O2.2HCl

cas num :

607378-18-7

USD :

243

USD 2025 :

251 USD

product details :

Potent P2X7 antagonist

more info or order :

Tocris Bioscience product webpage