AR-C 66096 tetrasodium salt | Tocris Bioscience 3321/1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AR-C 66096 tetrasodium salt

catalog :

3321/1

quantity :

1 mg

price :

469 USD

citations: 7

Reference
Lu W, Gómez N, Lim J, Guha S, O Brien Jenkins A, Coffey E, et al. The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol. 2018;9:242 pubmed publisher
Chan M, Leadbeater P, Watson S, Warner T. Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry. Platelets. 2018;29:686-689 pubmed publisher
Aungraheeta R, Conibear A, Butler M, Kelly E, Nylander S, Mumford A, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016;128:2717-2728 pubmed
Zhang J, Zhang K, Gao Z, Paoletta S, Zhang D, Han G, et al. Agonist-bound structure of the human P2Y12 receptor. Nature. 2014;509:119-22 pubmed publisher
Helms C, Marvel M, Zhao W, Stahle M, Vest R, Kato G, et al. Mechanisms of hemolysis-associated platelet activation. J Thromb Haemost. 2013;11:2148-54 pubmed publisher
Pinheiro A, Paramos de Carvalho D, Certal M, Costa C, Magalhães Cardoso M, Ferreirinha F, et al. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal. 2013;11:70 pubmed publisher
Gao Z, Wei Q, Jayasekara M, Jacobson K. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013;9:31-40 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3321

SKU :

3321/1

product name :

AR-C 66096 tetrasodium salt

Description :

Potent and selective P2Y12 antagonist

target :

P2Y Receptor Antagonists

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

703.26

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AR-C 66096 tetrasodium salt is a potent and selective P2Y12 receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).

extended description :

Potent and selective P2Y12 antagonist

chemical name text :

2-(Propylthio)adenosine-5 -O-( , -difluoromethylene)triphosphate tetrasodium salt

formula :

C 14 H 18 F 2 N 5 Na 4 O 12 P 3 S

formula text :

C14H18F2N5Na4O12P3S

cas num :

145782-74-7

USD :

469 USD

product details :

Potent and selective P2Y12 antagonist

alt names :

FPL 66096, ARL 66096

storage :

Store at -20°C