SC 514 | Tocris Bioscience 3318 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SC 514

catalog :

3318

quantity :

10 mg (also 50 mg)

price :

147 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Gurney L, Taggart J, Tong W, Jones A, Robson S, Taggart M. Inhibition of Inflammatory Changes in Human Myometrial Cells by Cell Penetrating Peptide and Small Molecule Inhibitors of NFκB. Front Immunol. 2018;9:2966 pubmed publisher
Cataldi M, Shah N, Felt S, Grdzelishvili V. Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1. Virology. 2015;485:340-54 pubmed publisher
Akhtar N, Makki M, Haqqi T. MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes. Arthritis Rheumatol. 2015;67:423-34 pubmed publisher

product information

brand :

Tocris

master code :

3318

SKU :

3318/10

product name :

SC 514

description :

IKK inhibitor; attenuates NF- B-induced gene expression

target :

IkB Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

224.3

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Orally active, ATP-competitive IKK inhibitor (IC50 = 3 - 12 M) that displays 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Attenuates NF- B-induced gene expression of IL-6, IL-8 and COX-2 in synovial fibroblasts (IC50 values are 20, 20 and 8 M respectively). Reduces iNOS induction and exhibits anti-inflammatory activity in vivo .

catalog number base :

3318

product keywords :

IKK-2 inhibitors inhibits attenuates NF- B NF-kappaB-induced gene expression NF-kB IKK I B IkappaB Kinases Nuclear Factor Kappa B NF-kappaB Cytokine Signaling Signalling Transcription Factors SC514 AstraZeneca NF-kB/IkB IkB Kinase 3318,

extended description :

IKK inhibitor; attenuates NF- B-induced gene expression

chemical name text :

4-Amino-[2 ,3 -bithiophene]-5-carboxamide

formula :

C 9 H 8 N 2 OS 2

formula text :

C9H8N2OS2

cas num :

354812-17-2

2020 USD :

144

2021 USD :

147 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage