AZ 11645373 | Tocris Bioscience 3317/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZ 11645373

catalog :

3317/10

quantity :

10 mg (also 50 mg)

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Weng N, Talbot P. The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cells. Stem Cell Res. 2017;23:39-49 pubmed publisher
Agrawal A, Henriksen Z, Syberg S, Petersen S, Aslan D, Solgaard M, et al. P2X7Rs are involved in cell death, growth and cellular signaling in primary human osteoblasts. Bone. 2017;95:91-101 pubmed publisher
Karmakar M, Katsnelson M, Dubyak G, Pearlman E. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1Î² secretion in response to ATP. Nat Commun. 2016;7:10555 pubmed publisher
Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS ONE. 2015;10:e0127919 pubmed publisher
Soares Bezerra R, Ferreira N, Alberto A, Bonavita A, Fidalgo Neto A, Calheiros A, et al. An Improved Method for P2X7R Antagonist Screening. PLoS ONE. 2015;10:e0123089 pubmed publisher
Sathanoori R, SwÃ¤rd K, Olde B, Erlinge D. The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells. PLoS ONE. 2015;10:e0125111 pubmed publisher
Bhaskaracharya A, Dao Ung P, Jalilian I, Spildrejorde M, Skarratt K, Fuller S, et al. Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. PLoS ONE. 2014;9:e93058 pubmed publisher
Asgari E, Le Friec G, Yamamoto H, Perucha E, Sacks S, Köhl J, et al. C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. Blood. 2013;122:3473-81 pubmed publisher
Foster J, Carter E, Kilty I, Mackenzie A, Ward S. Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes. J Immunol. 2013;190:1551-9 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3317

SKU :

3317/10

product name :

AZ 11645373

description :

Potent and selective human P2X7 antagonist

target :

P2X Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

463.51

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZ 11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1 release in vitro (KB values are 15 and 92 nM respectively).

product keywords :

Potent selective human P2X7 antagonists Receptors Purinergic purinoceptors AZ11645373 AstraZeneca P2X Receptors 3317,

extended description :

Potent and selective human P2X7 antagonist

chemical name text :

3-[1-[[(3 -Nitro[1,1 -biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

formula :

C24H21N3O5S

formula text :

C24H21N3O5S

cas num :

227088-94-0

USD :

261

USD 2025 :

264 USD

product details :

Potent and selective human P2X7 antagonist

more info or order :

Tocris Bioscience product webpage