PF 670462 | Tocris Bioscience 3316/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 670462

catalog :

3316/10

quantity :

10 mg (also 50 mg)

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Carr H, Zuo Y, Frost J. The Wnt pathway protein Dvl1 targets somatostatin receptor 2 for lysosome-dependent degradation. J Biol Chem. 2023;299:104645 pubmed publisher
Krulikas L, McDonald I, Lee B, Okumu D, East M, Gilbert T, et al. Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth. SLAS Discov. 2018;23:850-861 pubmed publisher
Zhang F, Virshup D, Cheong J. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. 2018;37:363-376 pubmed publisher
Greer Y, Gao B, Yang Y, Nussenzweig A, Rubin J. Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. PLoS ONE. 2017;12:e0170903 pubmed publisher
Patton A, Chesham J, Hastings M. Combined Pharmacological and Genetic Manipulations Unlock Unprecedented Temporal Elasticity and Reveal Phase-Specific Modulation of the Molecular Circadian Clock of the Mouse Suprachiasmatic Nucleus. J Neurosci. 2016;36:9326-41 pubmed publisher
Causton H, Feeney K, Ziegler C, O Neill J. Metabolic Cycles in Yeast Share Features Conserved among Circadian Rhythms. Curr Biol. 2015;25:1056-62 pubmed publisher
Cheong J, Zhang F, Chua P, Bay B, Thorburn A, Virshup D. Casein kinase 1Î±-dependent feedback loop controls autophagy in RAS-driven cancers. J Clin Invest. 2015;125:1401-18 pubmed publisher
KauckÃ¡ M, Petersen J, JanovskÃ¡ P, Radaszkiewicz T, SmyÄkovÃ¡ L, Daulat A, et al. Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway. Cell Commun Signal. 2015;13:2 pubmed publisher
Kurihara T, Sakurai E, Toyomoto M, Kii I, Kawamoto D, Asada T, et al. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Mol Pain. 2014;10:17 pubmed publisher
Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C, et al. CK1? and CK1? are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci. 2014;127:1242-53 pubmed publisher
Zhang L, Hastings M, Green E, Tauber E, Sladek M, Webster S, et al. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra. Curr Biol. 2013;23:1863-73 pubmed publisher
Zantke J, Ishikawa Fujiwara T, Arboleda E, Lohs C, Schipany K, Hallay N, et al. Circadian and circalunar clock interactions in a marine annelid. Cell Rep. 2013;5:99-113 pubmed publisher
Cajanek L, Ganji R, Henriques Oliveira C, Theofilopoulos S, Konik P, Bryja V, et al. Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol Cell Biol. 2013;33:59-70 pubmed publisher
Schepetkin I, Kirpotina L, Khlebnikov A, Hanks T, Kochetkova I, Pascual D, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012;81:832-45 pubmed publisher

product information

brand :

Tocris

catalog number base :

3316

SKU :

3316/10

product name :

PF 670462

units size :

10 mg (also 50 mg)

description :

Potent and selective CK1 and CK1 inhibitor

target :

Casein Kinase 1 Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

410.32

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 670462 is a potent and selective casein kinase 1 (CK1 ) and CK1 inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo .

top caption :

Potent and selective CK1 and CK1 inhibitor

extended description :

Potent and selective CK1 and CK1 inhibitor

chemical name text :

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride

formula :

C19H20FN5.2HCl

formula text :

C19H20FN5.2HCl

cas num :

950912-80-8

USD :

292 USD

product details :

Potent and selective CK1 and CK1 inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage