BI 78D3 | Tocris Bioscience 3314/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BI 78D3

catalog :

3314/10

quantity :

10 mg (also 50 mg)

price :

248 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Lahiri S, Lu H, Mukherjee D, Yu L, Zhao J. ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability. Am J Cancer Res. 2016;6:910-23 pubmed
Jang S, Yu L, Abdelmegeed M, Gao Y, Banerjee A, Song B. Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. Redox Biol. 2015;6:552-564 pubmed publisher
Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers C, et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013;11:e1001665 pubmed publisher
Gandham V, Maddala R, Rao V, Jin J, Epstein D, Hall R, et al. Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol. 2013;38:782-6 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3314

SKU :

3314/10

product name :

BI 78D3

description :

Selective, competitive JNK inhibitor

target :

JNK/c-jun Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

379.37

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays 100 fold selectivity over p38 and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.

product keywords :

Selective competitive JNK inhibitors inhibits MAPK Signaling Signalling c-Jun N-Terminal Kinases SAPKs Stress-Activated Protein Mitogen-Activated p38 BI78D3 JNK/c-jun 3314,

extended description :

Selective, competitive JNK inhibitor

chemical name text :

4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one

formula :

C13H9N5O5S2

formula text :

C13H9N5O5S2

cas num :

883065-90-5

USD :

275

USD 2025 :

248 USD

product details :

Selective, competitive JNK inhibitor

more info or order :

Tocris Bioscience product webpage