BI 78D3 | Tocris Bioscience 3314/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BI 78D3

catalog :

3314/10

quantity :

10 mg (also 50 mg)

price :

248 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Lahiri S, Lu H, Mukherjee D, Yu L, Zhao J. ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability. Am J Cancer Res. 2016;6:910-23 pubmed
Jang S, Yu L, Abdelmegeed M, Gao Y, Banerjee A, Song B. Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. Redox Biol. 2015;6:552-564 pubmed publisher
Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers C, et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013;11:e1001665 pubmed publisher
Gandham V, Maddala R, Rao V, Jin J, Epstein D, Hall R, et al. Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol. 2013;38:782-6 pubmed publisher

product information

brand :

Tocris

catalog number base :

3314

SKU :

3314/10

product name :

BI 78D3

units size :

10 mg (also 50 mg)

description :

Selective, competitive JNK inhibitor

target :

JNK/c-jun Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

379.37

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays 100 fold selectivity over p38 and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.

top caption :

Selective, competitive JNK inhibitor

extended description :

Selective, competitive JNK inhibitor

chemical name text :

4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one

formula :

C13H9N5O5S2

formula text :

C13H9N5O5S2

cas num :

883065-90-5

USD :

248 USD

product details :

Selective, competitive JNK inhibitor

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage