BzATP triethylammonium salt | Tocris Bioscience 3312/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BzATP triethylammonium salt

catalog :

3312/1

quantity :

1 mg

price :

103 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Pronin A, Pham D, An W, Dvoriantchikova G, Reshetnikova G, Qiao J, et al. Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury. Front Mol Neurosci. 2019;12:36 pubmed publisher
Wu X, Ren J, Chen G, Wu L, Song X, Li G, et al. Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption. Sci Rep. 2017;7:4364 pubmed publisher
Karmakar M, Katsnelson M, Dubyak G, Pearlman E. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1Î² secretion in response to ATP. Nat Commun. 2016;7:10555 pubmed publisher
Ilatovskaya D, Palygin O, Levchenko V, Staruschenko A. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol. 2013;305:C1050-9 pubmed publisher
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed publisher
Nörenberg W, Sobottka H, Hempel C, Plötz T, Fischer W, Schmalzing G, et al. Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol. 2012;167:48-66 pubmed publisher
Woehrle T, Yip L, Manohar M, Sumi Y, Yao Y, Chen Y, et al. Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors. J Leukoc Biol. 2010;88:1181-9 pubmed publisher

product information

brand :

Tocris

catalog number base :

3312

SKU :

3312/1

product name :

BzATP triethylammonium salt

units size :

1 mg

description :

Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist

target :

P2X Receptor Agonists

category :

Small Molecules

purity :

95%

observed molecular weight :

1018.97

url print :

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review stars :

details of functionality :

BzATP triethylammonium salt is a prototypic P2X7 receptor agonist (EC50 values are 3.6, 7 and 285 M for rat, human and mouse receptors respectively). Exhibits 5 - 10 fold greater potency than ATP. Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase. . This compound is a mixture of isomers.

top caption :

Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist

extended description :

Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist

chemical name text :

2 (3 )-O-(4-Benzoylbenzoyl)adenosine-5 -triphosphate tri(triethylammonium) salt

formula :

C24H24N5O15P3.C18H45N3

formula text :

C24H24N5O15P3.C18H45N3

USD :

103 USD

product details :

Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage