Zileuton | Tocris Bioscience 3308 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Zileuton

catalog :

3308

quantity :

10 mg (also 50 mg)

price :

63 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Oguh Olayinka L, Agarwal V, Ranatunge D, Campbell A, Laufer S, Cawkwell L, et al. The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res. 2019;: pubmed publisher
Li C, Deng X, Xie X, Liu Y, Friedmann Angeli J, Lai L. Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy. Front Pharmacol. 2018;9:1120 pubmed publisher
Sharma Walia N, Chandran K, Patel K, Veettil M, Marginean A. The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis. J Virol. 2014;88:2131-56 pubmed publisher
Chang T, Uen Y, Chou C, Sheu J, Chou D. The role of cyclooxygenase-derived oxidative stress in surgically induced lymphedema in a mouse tail model. Pharm Biol. 2013;51:573-80 pubmed publisher
Mothe Satney I, Filloux C, Amghar H, Pons C, Bourlier V, Galitzky J, et al. Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice. Diabetes. 2012;61:2311-9 pubmed publisher
Gregus A, Doolen S, Dumlao D, Buczynski M, Takasusuki T, Fitzsimmons B, et al. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A. 2012;109:6721-6 pubmed publisher
Jiang Z, Yin X, Jiang Q. Natural forms of vitamin E and 13'-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively. J Immunol. 2011;186:1173-9 pubmed publisher

product information

brand :

Tocris

master code :

3308

SKU :

3308/10

product name :

Zileuton

description :

5-LOX inhibitor; orally bioavailable

target :

Lipoxygenase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

236.29

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis (IC50 values are 0.56, 2.3 and 2.6 M in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC50 = 6 M) and exhibits antiasthmatic activity in vivo . Also weakly inhibits CYP1A2 (Ki = 66 - 98 M). Ferroptosis inhibitor.

catalog number base :

3308

product keywords :

Orally active 5-LOX inhibitors inhibits Lipoxygenase Oxygenases Oxidases ICID2138 5-LOX ferroptosis inhibitors inhibits ICI D2138 Lipoxygenase Ferroptosis 3308,

extended description :

5-LOX inhibitor; orally bioavailable

chemical name text :

N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea

formula :

C 11 H 12 N 2 O 2 S

formula text :

C11H12N2O2S

cas num :

111406-87-2

2020 USD :

2021 USD :

63 USD

alt names :

ICI D2138

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage