8-(3-Chlorostyryl)caffeine | Tocris Bioscience 3306/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8-(3-Chlorostyryl)caffeine

catalog :

3306/10

quantity :

10 mg (also 50 mg)

price :

124 USD

citations: 5

Reference
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
Benada J, BurdovÃ¡ K, Lidak T, von Morgen P, Macurek L. Polo-like kinase 1 inhibits DNA damage response during mitosis. Cell Cycle. 2015;14:219-31 pubmed publisher
Li H, Chuang A, O BRIEN J. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci. 2014;31:237-43 pubmed publisher
Bao Y, Chen Y, Ledderose C, Li L, Junger W. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J Biol Chem. 2013;288:22650-7 pubmed publisher
Factor P, Mutlu G, Chen L, Mohameed J, Akhmedov A, Meng F, et al. Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A. 2007;104:4083-8 pubmed

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3306

SKU :

3306/10

product name :

8-(3-Chlorostyryl)caffeine

Description :

Selective A2A antagonist. Also MAO-B inhibitor

target :

Adenosine A2a Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

330.77

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

8-(3-Chlorostyryl)caffeine is a selective adenosine A2A receptor antagonist and monoamine oxidase B (MAO-B) inhibitor (Ki values are 54 and 28200 nM at rat A2A and A1 receptors respectively and Ki ~ 100 nM at MAO-B). Potently protects against quinolinic acid -induced (Cat. No. 0225) neuronal damage and is neuroprotective in the MPTP model of Parkinson s disease.

extended description :

Selective A2A antagonist. Also MAO-B inhibitor

chemical name text :

(E)-8-[2-(3-Chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

formula :

C 16 H 15 ClN 4 O 2

formula text :

C16H15ClN4O2

cas num :

147700-11-6

USD :

124 USD

product details :

Selective A2A antagonist. Also MAO-B inhibitor

alt names :

CSC

storage :

Store at -20°C