SU 16f | Tocris Bioscience 3304/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SU 16f

catalog :

3304/10

quantity :

10 mg (also 50 mg)

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Novak S, Madunic J, Shum L, Vučetić M, Wang X, Tanigawa H, et al. PDGF inhibits BMP2-induced bone healing. NPJ Regen Med. 2023;8:3 pubmed publisher
Chatterjee S, Bhat V, Berdnikov A, Liu J, Zhang G, Buchel E, et al. Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth. iScience. 2019;19:388-401 pubmed publisher
Jiang Y, Berry D, Jo A, Tang W, Arpke R, Kyba M, et al. A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion. Nat Commun. 2017;8:15926 pubmed publisher
Andersen R, Zaher W, Larsen K, Ditzel N, Drews K, Wruck W, et al. Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells. Stem Cell Res Ther. 2015;6:196 pubmed publisher
Lee E, Pandey N, Popel A. Lymphatic endothelial cells support tumor growth in breast cancer. Sci Rep. 2014;4:5853 pubmed publisher

product information

brand :

Tocris

catalog number base :

3304

SKU :

3304/10

product name :

SU 16f

units size :

10 mg (also 50 mg)

description :

Potent and selective PDGFR inhibitor

target :

PDGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

386.44

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SU 16f is a potent and selective platelet-derived growth factor receptor (PDGFR ) inhibitor (IC50 = 10 nM) that displays 14-fold, 229-fold and 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 M). Promotes conversion of fibroblasts to cardiomyocytes as part of 9C cocktail (see our protocol below). . For more information about how SU 16f may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

top caption :

Potent and selective PDGFR inhibitor

extended description :

Potent and selective PDGFR inhibitor

chemical name text :

5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid

formula :

C24H22N2O3

formula text :

C24H22N2O3

cas num :

251356-45-3

USD :

292 USD

product details :

Potent and selective PDGFR inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage