NU 6140 | Tocris Bioscience 3301/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NU 6140

catalog :

3301/10

quantity :

10 mg

price :

278 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Musa J, Cidre Aranaz F, Aynaud M, Orth M, Knott M, Mirabeau O, et al. Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. Nat Commun. 2019;10:4128 pubmed publisher
Berenjeno I, Piñeiro R, Castillo S, Pearce W, McGranahan N, Dewhurst S, et al. Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. Nat Commun. 2017;8:1773 pubmed publisher
Zhang H, Alshareef A, Wu C, Jiao J, Sorensen P, Lai R, et al. miR-200b induces cell cycle arrest and represses cell growth in esophageal squamous cell carcinoma. Carcinogenesis. 2016;37:858-869 pubmed publisher
Boekhout M, Yuan R, Wondergem A, Segeren H, van Liere E, Awol N, et al. Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression. EMBO Rep. 2016;17:414-27 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3301

SKU :

3301/10

product name :

NU 6140

Description :

Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

99%

observed molecular weight :

422.52

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor (IC50 values are 0.42 - 1.1 M). Displays some selectivity for cdk2 (IC50 value = 0.94 M for cdk4 and >2.3 M for other cdks). Induces cell-cycle arrest at the G2-M phase. Potentiates the apoptotic effect of taxol (Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin. Also potently inhibits aurora kinases (IC50 values are 0.035 and 0.067 M for aurora kinase B and A, respectively).

extended description :

Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

chemical name text :

4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide

formula :

C 23 H 30 N 6 O 2

formula text :

C23H30N6O2

cas num :

444723-13-1

USD :

278 USD

product details :

Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage