SU 5402 | Tocris Bioscience 3300 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SU 5402

catalog :

3300

quantity :

1 mg

price :

258 USD

more info or order :

Tocris Bioscience product webpage

citations: 17

Reference
Gibb N, Lazic S, Yuan X, Deshwar A, Leslie M, Wilson M, et al. Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development. 2018;145: pubmed publisher
Yang J, Ryan D, Wang W, Tsang J, Lan G, Masaki H, et al. Establishment of mouse expanded potential stem cells. Nature. 2017;550:393-397 pubmed publisher
Yan C, Yang Q, Huo X, Li H, Zhou L, Gong Z. Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep. 2017;7:45796 pubmed publisher
Rodrigues A, Yakushiji Kaminatsui N, Atsuta Y, Andrey G, Schorderet P, Duboule D, et al. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells. Proc Natl Acad Sci U S A. 2017;114:3139-3144 pubmed publisher
Li M, Page McCaw P, Chen W. FGF1 Mediates Overnutrition-Induced Compensatory Î²-Cell Differentiation. Diabetes. 2016;65:96-109 pubmed publisher
Cunningham T, Brade T, Sandell L, Lewandoski M, Trainor P, Colas A, et al. Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis. PLoS ONE. 2015;10:e0137894 pubmed publisher
Benzina S, Pitaval A, Lemercier C, Lustremant C, Frouin V, Wu N, et al. A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. Cell Mol Life Sci. 2015;72:3559-73 pubmed publisher
Dean B, Erdoğan B, Gamse J, Wu S. Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Neural Dev. 2014;9:20 pubmed publisher
Chen J, Galloway J. The development of zebrafish tendon and ligament progenitors. Development. 2014;141:2035-45 pubmed publisher
Bernet J, Doles J, Hall J, Kelly Tanaka K, Carter T, Olwin B. p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nat Med. 2014;20:265-71 pubmed publisher
Dai W, Bai Y, Hebda L, Zhong X, Liu J, Kao J, et al. Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Cell Death Differ. 2014;21:568-81 pubmed publisher
Neugebauer J, Yost H. FGF signaling is required for brain left-right asymmetry and brain midline formation. Dev Biol. 2014;386:123-34 pubmed publisher
Hashiguchi M, Mullins M. Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Development. 2013;140:1970-80 pubmed publisher
Clanton J, Hope K, Gamse J. Fgf signaling governs cell fate in the zebrafish pineal complex. Development. 2013;140:323-32 pubmed publisher
Rankin S, Gallas A, Neto A, Gomez Skarmeta J, Zorn A. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Development. 2012;139:3010-20 pubmed publisher
Sato A, Scholl A, Kuhn E, Kuhn E, Stadt H, Decker J, et al. FGF8 signaling is chemotactic for cardiac neural crest cells. Dev Biol. 2011;354:18-30 pubmed publisher
Tan T, Tang X, Zhang J, Niu Y, Chen H, Li B, et al. Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4. PLoS ONE. 2011;6:e17124 pubmed publisher

product information

brand :

Tocris

master code :

3300

SKU :

3300/1

product name :

SU 5402

description :

Potent FGFR and VEGFR inhibitor

target :

FGF Receptor Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

95%

observed molecular weight :

296.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and 100 M at VEGFR2, FGFR1, PDGFR and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo . Also attenuates integrin 4-induced differentiation of neural stem cells. Supports mESC self-renewal.

catalog number base :

3300

product keywords :

Potent VEGFR FGFR inhibitors inhibits Vascular Endothelial Growth Factor Receptors KDR Flt Receptor Tyrosine Kinases RTKs Fibroblast SU5402 neural stem cells differentiation FGFR VEGFR Neural Stem Cells Stem Cell Proliferation 3300,

extended description :

Potent FGFR and VEGFR inhibitor

chemical name text :

2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid

formula :

C 17 H 16 N 2 O 3

formula text :

C17H16N2O3

cas num :

215543-92-3

2020 USD :

245

2021 USD :

258 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage