AMD 3100 octahydrochloride | Tocris Bioscience 3299 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AMD 3100 octahydrochloride

catalog :

3299

quantity :

10 mg (also 50 mg)

price :

165 USD

more info or order :

Tocris Bioscience product webpage

citations: 16

Reference
He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed publisher
Arjunan P, Meghil M, Pi W, Xu J, Lang L, El Awady A, et al. Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation. Sci Rep. 2018;8:16607 pubmed publisher
Griffiths K, Habiel D, Jaffar J, Binder U, Darby W, Hosking C, et al. Anti-fibrotic Effects of CXCR4-Targeting i-body AD-114 in Preclinical Models of Pulmonary Fibrosis. Sci Rep. 2018;8:3212 pubmed publisher
Sakitani K, Hayakawa Y, Deng H, Ariyama H, Kinoshita H, Konishi M, et al. CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development. Oncotarget. 2017;8:111012-111025 pubmed publisher
Ahmed M, Basheer H, Ayuso J, Ahmet D, Mazzini M, Patel R, et al. Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines. Sci Rep. 2017;7:1075 pubmed publisher
Cavnar S, Rickelmann A, Meguiar K, Xiao A, Dosch J, Leung B, et al. Modeling selective elimination of quiescent cancer cells from bone marrow. Neoplasia. 2015;17:625-33 pubmed publisher
Chu P, Walder K, Horlock D, Williams D, Nelson E, Byrne M, et al. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS ONE. 2015;10:e0133616 pubmed publisher
Kouzoukas D, Meyer Siegler K, Ma F, Westlund K, Hunt D, Vera P. Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain. PLoS ONE. 2015;10:e0127628 pubmed publisher
Beck T, Gomes A, Cyster J, Pereira J. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med. 2014;211:2567-81 pubmed publisher
Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination. J Neurosci. 2014;34:8646-58 pubmed publisher
Farkas D, Kraskauskas D, Drake J, Alhussaini A, Kraskauskiene V, Bogaard H, et al. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit? cells in rats. PLoS ONE. 2014;9:e89810 pubmed publisher
Zhang X, Jin X, Malladi S, Zou Y, Wen Y, Brogi E, et al. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 2013;154:1060-1073 pubmed publisher
Casanova Acebes M, Pitaval C, Weiss L, Nombela Arrieta C, Chevre R, A Gonzalez N, et al. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell. 2013;153:1025-35 pubmed publisher
Ray P, Lewin S, Mihalko L, Schmidt B, Luker K, Luker G. Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4. Neoplasia. 2011;13:1152-61 pubmed
Laschke M, Giebels C, Nickels R, Scheuer C, Menger M. Endothelial progenitor cells contribute to the vascularization of endometriotic lesions. Am J Pathol. 2011;178:442-50 pubmed publisher
Chigaev A, Wu Y, Williams D, Smagley Y, Sklar L. Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. J Biol Chem. 2011;286:5455-63 pubmed publisher

product information

brand :

Tocris

master code :

3299

SKU :

3299/10

product name :

AMD 3100 octahydrochloride

description :

Highly selective CXCR4 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

794.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and 25 M for CXCR4 and most other chemokine receptors, respectively). Also CXCR7 allosteric agonist. Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo . Attenuates cocaine place preference and locomotor stimulation in rats. Attenuates microglial activation neurological function after ischemic stroke in mice. Inhibits tumor cell migration and proliferation in vitro and in vivo in a range of cancers.

catalog number base :

3299

product keywords :

selective CXCR4 antagonists Chemokine Receptors AMD3100 octahydrochloride JM3100 HSC hematopoietic haematopoietic stem cells mobilization JM 3100 Plerixafor Stem Cell Signaling Chemokine CXC Receptors 3299,

extended description :

Highly selective CXCR4 antagonist

chemical name text :

1,1 -[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride

formula :

C 28 H 54 N 8 .8HCl

formula text :

C28H54N8.8HCl

cas num :

155148-31-5

2020 USD :

157

2021 USD :

165 USD

alt names :

JM 3100, Plerixafor

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage