AMD 3100 octahydrochloride | Tocris Bioscience 3299/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AMD 3100 octahydrochloride

catalog :

3299/10

quantity :

10 mg (also 50 mg)

price :

218 USD

more info or order :

Tocris Bioscience product webpage

citations: 21

Reference
He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed publisher
Arjunan P, Meghil M, Pi W, Xu J, Lang L, El Awady A, et al. Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation. Sci Rep. 2018;8:16607 pubmed publisher
Griffiths K, Habiel D, Jaffar J, Binder U, Darby W, Hosking C, et al. Anti-fibrotic Effects of CXCR4-Targeting i-body AD-114 in Preclinical Models of Pulmonary Fibrosis. Sci Rep. 2018;8:3212 pubmed publisher
Sakitani K, Hayakawa Y, Deng H, Ariyama H, Kinoshita H, Konishi M, et al. CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development. Oncotarget. 2017;8:111012-111025 pubmed publisher
Ahmed M, Basheer H, Ayuso J, Ahmet D, Mazzini M, Patel R, et al. Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines. Sci Rep. 2017;7:1075 pubmed publisher
Desplantes R, Leveque C, Müller B, Lotierzo M, Ferracci G, Popoff M, et al. Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor. Sci Rep. 2017;7:1032 pubmed publisher
Griffiths K, Dolezal O, Cao B, Nilsson S, See H, Pfleger K, et al. i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4. J Biol Chem. 2016;291:12641-57 pubmed publisher
Cavnar S, Rickelmann A, Meguiar K, Xiao A, Dosch J, Leung B, et al. Modeling selective elimination of quiescent cancer cells from bone marrow. Neoplasia. 2015;17:625-33 pubmed publisher
Chu P, Walder K, Horlock D, Williams D, Nelson E, Byrne M, et al. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS ONE. 2015;10:e0133616 pubmed publisher
Kouzoukas D, Meyer Siegler K, Ma F, Westlund K, Hunt D, Vera P. Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain. PLoS ONE. 2015;10:e0127628 pubmed publisher
Beck T, Gomes A, Cyster J, Pereira J. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med. 2014;211:2567-81 pubmed publisher
Walsh T, Harper M, Poole A. SDF-1Î± is a novel autocrine activator of platelets operating through its receptor CXCR4. Cell Signal. 2015;27:37-46 pubmed publisher
Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination. J Neurosci. 2014;34:8646-58 pubmed publisher
Farkas D, Kraskauskas D, Drake J, Alhussaini A, Kraskauskiene V, Bogaard H, et al. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit? cells in rats. PLoS ONE. 2014;9:e89810 pubmed publisher
Miles B, Zakhary I, El Awady A, Scisci E, CARRION J, O Neill J, et al. Secondary lymphoid organ homing phenotype of human myeloid dendritic cells disrupted by an intracellular oral pathogen. Infect Immun. 2014;82:101-11 pubmed publisher
Zhang X, Jin X, Malladi S, Zou Y, Wen Y, Brogi E, et al. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 2013;154:1060-1073 pubmed publisher
Casanova Acebes M, Pitaval C, Weiss L, Nombela Arrieta C, Chevre R, A Gonzalez N, et al. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell. 2013;153:1025-35 pubmed publisher
Winkler I, Pettit A, Raggatt L, Jacobsen R, Forristal C, Barbier V, et al. Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia. 2012;26:1594-601 pubmed publisher
Ray P, Lewin S, Mihalko L, Schmidt B, Luker K, Luker G. Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4. Neoplasia. 2011;13:1152-61 pubmed
Laschke M, Giebels C, Nickels R, Scheuer C, Menger M. Endothelial progenitor cells contribute to the vascularization of endometriotic lesions. Am J Pathol. 2011;178:442-50 pubmed publisher
Chigaev A, Wu Y, Williams D, Smagley Y, Sklar L. Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. J Biol Chem. 2011;286:5455-63 pubmed publisher

product information

brand :

Tocris

catalog number base :

3299

SKU :

3299/10

product name :

AMD 3100 octahydrochloride

units size :

10 mg (also 50 mg)

description :

Highly selective CXCR4 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

observed molecular weight :

794.48

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AMD 3100 octahydrochloride is a highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and 25 M for CXCR4 and most other chemokine receptors, respectively). Also CXCR7 allosteric agonist. Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo . Attenuates cocaine place preference and locomotor stimulation in rats. Attenuates microglial activation neurological function after ischemic stroke in mice. Inhibits tumor cell migration and proliferation in vitro and in vivo in a range of cancers.

top caption :

Highly selective CXCR4 antagonist

extended description :

Highly selective CXCR4 antagonist

chemical name text :

1,1 -[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride

formula :

C28H54N8.8HCl

formula text :

C28H54N8.8HCl

cas num :

155148-31-5

USD :

218 USD

product details :

Highly selective CXCR4 antagonist

alt names :

JM 3100,Plerixafor

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage