AP 18 | Tocris Bioscience 3296/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AP 18

catalog :

3296/10

quantity :

10 mg (also 50 mg)

price :

174 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Izzo A, Capasso R, Aviello G, Borrelli F, Romano B, Piscitelli F, et al. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. Br J Pharmacol. 2012;166:1444-60 pubmed publisher
Capasso R, Aviello G, Romano B, Borrelli F, De Petrocellis L, Di Marzo V, et al. Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects. Br J Pharmacol. 2012;165:1966-1977 pubmed publisher

image

image 1 :

Cat.No. 3296 - AP 18 C11H12ClNO CAS No. 55224-94-7

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3296

SKU :

3296/10

product name :

AP 18

Description :

Reversible TRPA1 channel blocker

target :

TRPA1 Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

209.67

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AP 18 is a reversible TRPA1 channel blocker (IC50 values are 3.1 and 4.5 M at human and mouse TRPA1 respectively). Blocks cinnamaldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC50 = 10.3 M for the inhibition of Yo-Pro uptake).

extended description :

Reversible TRPA1 channel blocker

chemical name text :

4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime

formula :

C 11 H 12 ClNO

formula text :

C11H12ClNO

cas num :

55224-94-7

USD :

174 USD

product details :

Reversible TRPA1 channel blocker

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage