RG 108 | Tocris Bioscience 3295/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RG 108

catalog :

3295/10

quantity :

10 mg (also 50 mg)

price :

202 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Kottakis F, Nicolay B, Roumane A, Karnik R, Gu H, Nagle J, et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016;539:390-395 pubmed publisher
Zhang M, Lin Y, Sun Y, Zhu S, Zheng J, Liu K, et al. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016;18:653-67 pubmed publisher
Park H, Choi Y, Kim J, Chun H, Im I, Yoon S, et al. Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes. PLoS ONE. 2015;10:e0132992 pubmed publisher
Nugent B, Wright C, Shetty A, Hodes G, Lenz K, Mahurkar A, et al. Brain feminization requires active repression of masculinization via DNA methylation. Nat Neurosci. 2015;18:690-7 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3295

SKU :

3295/10

product name :

RG 108

description :

Non-nucleoside DNA methyltransferase inhibitor

target :

Methyltransferase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at RT

observed molecular weight :

334.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RG 108 is a non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.

product keywords :

Non-nucleoside DNA methyltransferase inhibitor inhibitors transferases RG108 inhibits DNA methylation dnmt epigenetics DNA Methyltransferases Stem Cell Reprogramming 3295,

extended description :

Non-nucleoside DNA methyltransferase inhibitor

chemical name text :

N-Phthalyl-L-tryptophan

formula :

C19H14N2O4

formula text :

C19H14N2O4

cas num :

48208-26-0

USD :

200

USD 2025 :

202 USD

product details :

Non-nucleoside DNA methyltransferase inhibitor

more info or order :

Tocris Bioscience product webpage