RG 108 | Tocris Bioscience 3295/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RG 108

catalog :

3295/10

quantity :

10 mg (also 50 mg)

price :

202 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Kottakis F, Nicolay B, Roumane A, Karnik R, Gu H, Nagle J, et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016;539:390-395 pubmed publisher
Zhang M, Lin Y, Sun Y, Zhu S, Zheng J, Liu K, et al. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016;18:653-67 pubmed publisher
Park H, Choi Y, Kim J, Chun H, Im I, Yoon S, et al. Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes. PLoS ONE. 2015;10:e0132992 pubmed publisher
Nugent B, Wright C, Shetty A, Hodes G, Lenz K, Mahurkar A, et al. Brain feminization requires active repression of masculinization via DNA methylation. Nat Neurosci. 2015;18:690-7 pubmed publisher

product information

brand :

Tocris

catalog number base :

3295

SKU :

3295/10

product name :

RG 108

units size :

10 mg (also 50 mg)

description :

Non-nucleoside DNA methyltransferase inhibitor

target :

Methyltransferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

334.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

RG 108 is a non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.

top caption :

Non-nucleoside DNA methyltransferase inhibitor

extended description :

Non-nucleoside DNA methyltransferase inhibitor

chemical name text :

N-Phthalyl-L-tryptophan

formula :

C19H14N2O4

formula text :

C19H14N2O4

cas num :

48208-26-0

USD :

202 USD

product details :

Non-nucleoside DNA methyltransferase inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage