product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Metyrapone
catalog :
3292/50
quantity :
50 mg
price :
111 USD
more info or order :
citations: 4
Reference
Pierce H, Zhang D, Magnon C, Lucas D, Christin J, Huggins M, et al. Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay. Cell Stem Cell. 2017;20:648-658.e4 pubmed publisher
Taves M, Plumb A, Korol A, Van Der Gugten J, Holmes D, Abraham N, et al. Lymphoid organs of neonatal and adult mice preferentially produce active glucocorticoids from metabolites, not precursors. Brain Behav Immun. 2016;57:271-281 pubmed publisher
Rincón Cortés M, Barr G, Mouly A, Shionoya K, Nuñez B, Sullivan R. Enduring good memories of infant trauma: rescue of adult neurobehavioral deficits via amygdala serotonin and corticosterone interaction. Proc Natl Acad Sci U S A. 2015;112:881-6 pubmed publisher
Liu Z, Song C, Wang M, He Y, Xu X, Pan H, et al. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain. 2014;7:32 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3292
SKU :
3292/50
product name :
Metyrapone
description :
11- hydroxylase inhibitor
target :
Hydroxylase Inhibitors
unit size :
50 mg
category :
Small Molecules
purity :
98%
storage :
Store at +4°C
observed molecular weight :
226.27
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Metyrapone is a cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11- hydroxylase (CYP11B1) activity (IC50 = 7.83 M). Also inhibits CYP3A4 and cytochrome P450-mediated / -1 hydroxylase activity.
product keywords :
steroid 11- 11-beta hydroxylase inhibitors inhibits Cytochrome P450 CYP11B1 CYP3A4 omega/ω-1 omega-1 Hydroxylases Cytochrome P450 3292,
extended description :
11- hydroxylase inhibitor
chemical name text :
2-Methyl-1,2-di-3-pyridinyl-1-propanone
formula :
C14H14N2O
formula text :
C14H14N2O
cas num :
54-36-4
USD :
107
USD 2025 :
111 USD
product details :
11- hydroxylase inhibitor
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK