PF 915275 | Tocris Bioscience 3291/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 915275

catalog :

3291/10

quantity :

10 mg (also 50 mg)

price :

203 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Chang L, Wun W, Wang P. An inhibitor of 11-β hydroxysteroid dehydrogenase type 1 (PF915275) alleviates nonylphenol-induced hyperadrenalism and adiposity in rat and human cells. BMC Pharmacol Toxicol. 2018;19:45 pubmed publisher
Matsumura S, Terao M, Itami S, Katayama I. Local cortisol activation is involved in EGF-induced immunosuppression. Dermatoendocrinol. 2017;9:e1412018 pubmed publisher
Youm J, Park K, Uchida Y, Chan A, Mauro T, Holleran W, et al. Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing. Wound Repair Regen. 2013;21:715-22 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3291

SKU :

3291/10

product name :

PF 915275

description :

Potent and selective 11 -hydroxysteroid dehydrogenase inhibitor

target :

11 beta-HSD Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

350.39

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 915275 is a potent and selective 11 -hydroxysteroid dehydrogenase type 1 (11 HSD1) inhibitor (Ki = 2.3 nM) that displays little activity at 11 HSD2 (1.5% inhibition at 10 M). Inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro (EC50 = 15 nM) and has antidiabetic activity in vivo . Orally active.

product keywords :

Potent selective 11 -hydroxysteroid beta-hydroxysteroid dehydrogenases type 1 11 HSD1 11betaHSD1 inhibitors inhibits PF915275 11b-Hydroxysteroid Dehydrogenase 3291,

extended description :

Potent and selective 11 -hydroxysteroid dehydrogenase inhibitor

chemical name text :

N-(6-Amino-2-pyridinyl)-4 -cyano-[1,1 -biphenyl]-4-sulfonamide

formula :

C18H14N4O2S

formula text :

C18H14N4O2S

cas num :

857290-04-1

USD :

225

USD 2025 :

203 USD

product details :

Potent and selective 11 -hydroxysteroid dehydrogenase inhibitor

more info or order :

Tocris Bioscience product webpage