LY 487379 hydrochloride | Tocris Bioscience 3283 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LY 487379 hydrochloride

catalog :

3283

quantity :

10 mg (also 50 mg)

price :

184 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Scholler P, Nevoltris D, De Bundel D, Bossi S, Moreno Delgado D, Rovira X, et al. Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation. Nat Commun. 2017;8:1967 pubmed publisher
Motolese M, Mastroiacovo F, Cannella M, Bucci D, Gaglione A, Riozzi B, et al. Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage. Mol Brain. 2015;8:66 pubmed publisher
Copeland C, Neale S, Salt T. Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. Neuropharmacology. 2015;92:16-24 pubmed publisher
Yin S, Noetzel M, Johnson K, Zamorano R, Jalan Sakrikar N, Gregory K, et al. Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci. 2014;34:79-94 pubmed publisher

product information

brand :

Tocris

master code :

3283

SKU :

3283/10

product name :

LY 487379 hydrochloride

description :

Selective positive allosteric modulator of mGlu2 receptors

target :

Group II mGluR Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

488.91

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Positive allosteric modulator selective for mGlu2 receptors. Potentiates glutamate-stimulated [35S]GTP S binding (EC50 values are 1.7 and 10 u M for mGlu2 and mGlu3 receptors respectively). Devoid of any activity at mGlu5 and mGlu7 receptors. Promotes cognitive flexibility in a rat model.

catalog number base :

3283

product keywords :

Positive allosteric modulators pam selective mGlu2 mGluR2 mGlur Group II Receptors Glutamate Metabotropic LY487379 hydrochloride Glutamate (Metabotropic) Group II Receptors 3283,

extended description :

Selective positive allosteric modulator of mGlu2 receptors

chemical name text :

2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride

formula :

C 21 H 19 F 3 N 2 O 4 S.HCl

formula text :

C21H19F3N2O4S.HCl

cas num :

353229-59-1

2020 USD :

176

2021 USD :

184 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage