LY 487379 hydrochloride | Tocris Bioscience 3283/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LY 487379 hydrochloride

catalog :

3283/10

quantity :

10 mg (also 50 mg)

price :

232 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Scholler P, Nevoltris D, De Bundel D, Bossi S, Moreno Delgado D, Rovira X, et al. Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation. Nat Commun. 2017;8:1967 pubmed publisher
Motolese M, Mastroiacovo F, Cannella M, Bucci D, Gaglione A, Riozzi B, et al. Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage. Mol Brain. 2015;8:66 pubmed publisher
Copeland C, Neale S, Salt T. Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. Neuropharmacology. 2015;92:16-24 pubmed publisher
Yin S, Noetzel M, Johnson K, Zamorano R, Jalan Sakrikar N, Gregory K, et al. Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci. 2014;34:79-94 pubmed publisher

product information

brand :

Tocris

catalog number base :

3283

SKU :

3283/10

product name :

LY 487379 hydrochloride

units size :

10 mg (also 50 mg)

description :

Selective positive allosteric modulator of mGlu2 receptors

target :

Group II mGluR Modulators

category :

Small Molecules

purity :

98%

observed molecular weight :

488.91

url print :

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details of functionality :

LY 487379 hydrochloride is a positive allosteric modulator selective for mGlu2 receptors. Potentiates glutamate-stimulated [35S]GTP S binding (EC50 values are 1.7 and 10 u M for mGlu2 and mGlu3 receptors respectively). Devoid of any activity at mGlu5 and mGlu7 receptors. Promotes cognitive flexibility in a rat model.

top caption :

Selective positive allosteric modulator of mGlu2 receptors

extended description :

Selective positive allosteric modulator of mGlu2 receptors

chemical name text :

2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride

formula :

C21H19F3N2O4S.HCl

formula text :

C21H19F3N2O4S.HCl

cas num :

353229-59-1

USD :

232 USD

product details :

Selective positive allosteric modulator of mGlu2 receptors

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage