chemical

Compound 401

3271

10 mg

137 USD

3271

3271/10

Compound 401

Selective DNA-PK and mTOR inhibitor

DNA-dependent Protein Kinase Inhibitors

Small Molecules

10 mg

99%

281.31

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Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 u M respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC50 values are all 100 u M). Induces apoptosis in vitro .

3271

Selective DNA-PK mTOR inhibitors inhibits Checkpoint Control Kinases DNA-Dependent Protein Kinase PI3K Phosphoinositide PI 3-kinase Akt Signaling Signalling Mammalian Target Rapamycin FRAP Compound401 DNA-dependent Protein Kinase mTOR Checkpoint Control Kinases 3271,

Selective DNA-PK and mTOR inhibitor

2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one

C 16 H 15 N 3 O 2

C16H15N3O2

168425-64-7

137

137 USD

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