product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
GIT 27
catalog :
3270/10
quantity :
10 mg (also 50 mg)
price :
154 USD
more info or order :
citations: 1
Reference
Saurus P, Kuusela S, Lehtonen E, Hyvönen M, Ristola M, Fogarty C, et al. Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway. Cell Death Dis. 2015;6:e1752 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3270
SKU :
3270/10
product name :
GIT 27
description :
Immunomodulator; reduces production of pro-inflammatory cytokines
target :
Cytokine Compounds
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at +4°C
observed molecular weight :
205.21
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
GIT 27 is an orally active immunomodulatory agent that primarily targets macrophages. Inhibits TNF- secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. Also reduces the secretion of pro-inflammatory cytokines IL1- , IL-10 and IFN- . Antidiabetogenic; prevents IL- and IFN- -induced pancreatic islet cell death in vitro .
product keywords :
Interfers TLR4 TLR2/6 signalling Immunomodulators reduces production pro-inflammatory cytokines Toll-like Receptors TNF- TNF-alpha Interleukins Tumor Necrosis Factor- Factor-alpha Cytokines Cytokine NF- B NF-kappaB Signaling Signalling GI Cytokines Toll-like Receptors 3270,
extended description :
Immunomodulator; reduces production of pro-inflammatory cytokines
chemical name text :
4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid
formula :
C11H11NO3
formula text :
C11H11NO3
cas num :
6501-72-0
USD :
152
USD 2025 :
154 USD
product details :
Immunomodulator; reduces production of pro-inflammatory cytokines
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK