Thiostrepton | Tocris Bioscience 3267 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Thiostrepton

catalog :

3267

quantity :

50 mg

price :

74 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Huang C, Zhang X, Jiang L, Zhang L, Xiang M, Ren H. FoxM1 Induced Paclitaxel Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter. Mol Ther Oncolytics. 2019;14:196-212 pubmed publisher
Lin J, Zheng Y, Chen K, Huang Z, Wu X, Zhang N. Inhibition of FOXM1 by thiostrepton sensitizes medulloblastoma to the effects of chemotherapy. Oncol Rep. 2013;30:1739-44 pubmed publisher
Uddin S, Ahmed M, Hussain A, Abubaker J, Al Sanea N, AbdulJabbar A, et al. Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy. Am J Pathol. 2011;178:537-47 pubmed publisher

product information

brand :

Tocris

master code :

3267

SKU :

3267/50

product name :

Thiostrepton

description :

Antibiotic, inhibits protein synthesis

target :

Antibiotics

category :

Small Molecules

unit size :

50 mg

purity :

90%

observed molecular weight :

1664.89

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.

catalog number base :

3267

product keywords :

Downregulates FOXM1 Antibiotics inhibits inhibitors Hh Signaling Signalling Hedgehog Transcription Factors protein synthesis DNA, RNA and Protein Synthesis Hedgehog Signaling Other Transcription Factors Antibiotics 3267,

extended description :

Antibiotic, inhibits protein synthesis

formula :

C 72 H 85 N 19 O 18 S 5

formula text :

C72H85N19O18S5

cas num :

1393-48-2

2020 USD :

2021 USD :

74 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage