GW 788388 | Tocris Bioscience 3264 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 788388

catalog :

3264

quantity :

10 mg (also 50 mg)

price :

259 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Roux S, Borbely G, SÅ‚oniecka M, Backman L, Danielson P. Transforming Growth Factor Beta 1 Modulates the Functional Expression of the Neurokinin-1 Receptor in Human Keratocytes. Curr Eye Res. 2016;41:1035-1043 pubmed
Woods L, Camden J, El Sayed F, Khalafalla M, Petris M, Erb L, et al. Increased Expression of TGF-Î² Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation. PLoS ONE. 2015;10:e0123641 pubmed publisher
Castillero E, Akashi H, Wang C, Najjar M, Ji R, Kennel P, et al. Cardiac myostatin upregulation occurs immediately after myocardial ischemia and is involved in skeletal muscle activation of atrophy. Biochem Biophys Res Commun. 2015;457:106-11 pubmed publisher
Jajosky A, Coad J, Vos J, Martin K, Senft J, Wenger S, et al. RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. Stem Cells Transl Med. 2014;3:836-48 pubmed publisher

product information

brand :

Tocris

master code :

3264

SKU :

3264/10

product name :

GW 788388

description :

Potent and selective inhibitor of TGF- RI

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

425.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of transforming growth factor- type I receptor (ALK5) (IC50 values are 18 and 93 nM for ALK5 binding and for TGF- cellular assay respectively). Inhibits esophageal squamous cell carcinoma (ESCC)-induced neoangiogenesis. Reduces renal fibrosis in vivo . Orally active.

catalog number base :

3264

product keywords :

GW788388 transforming growth factor type I receptors tgfbeta tgfb tgf inhibitors inhibits TGF- RI TGF-beta Receptors 3264,

extended description :

Potent and selective inhibitor of TGF- RI

chemical name text :

4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide

formula :

C 25 H 23 N 5 O 2

formula text :

C25H23N5O2

cas num :

452342-67-5

2020 USD :

249

2021 USD :

259 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage