SB 505124 | Tocris Bioscience 3263 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 505124

catalog :

3263

quantity :

10 mg (also 50 mg)

price :

259 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Asghar K, Brain J, Palmer J, Douglass S, Naemi F, O Boyle G, et al. Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis. Oncol Lett. 2017;14:5497-5504 pubmed publisher
Yang J, Ryan D, Wang W, Tsang J, Lan G, Masaki H, et al. Establishment of mouse expanded potential stem cells. Nature. 2017;550:393-397 pubmed publisher
Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, et al. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene. 2016;35:5388-5399 pubmed publisher
Van Boxtel A, Chesebro J, Heliot C, Ramel M, Stone R, Hill C. A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. Dev Cell. 2015;35:175-85 pubmed publisher
Ramel M, Hill C. The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Dev Biol. 2013;378:170-82 pubmed publisher

product information

brand :

Tocris

master code :

3263

SKU :

3263/10

product name :

SB 505124

description :

Selective inhibitor of TGF- RI, ALK4 and ALK7

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

335.4

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of transforming growth factor- type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF- and activin; does not inhibit other ALK family members.

catalog number base :

3263

product keywords :

SB505124 tgf tgfbeta tgfb tgfbrI tgfbetarI tgf rI receptors transforming growth factors alk5 alk4 alk7 inhibitors inhibits TGF-beta Receptors BMP and Other Activin Receptors ALK 3263,

extended description :

Selective inhibitor of TGF- RI, ALK4 and ALK7

chemical name text :

2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine

formula :

C 20 H 21 N 3 O 2

formula text :

C20H21N3O2

cas num :

694433-59-5

2020 USD :

249

2021 USD :

259 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage